Biography:

MD, PhD since 1986, Teaching in medical colleges for more than 30 years. Head of department of Physiology in AGU since 5 years. Professor and researcher in Utrecht University/ College of Medicine/ Rudolf Magnus Institute for Neurosciences/ The Netherlands (1994-2005). Leading author of more than 50 articles on electrophysiology of DM (and others) in international journals.

Abstract:

The aim of this study was to investigate the effect of Caffeine consumption in learning and memory in Streptozotocin (STZ, 60 mg/ kg i.p) -induced DM in mice.

First; the NMDA (N-methyl-D-aspartate) component of the field excitatory post synaptic potential (fEPSP) was determined by extracellular recording from hippocampal slices prepared from STZ-induced DM and control animals. Later, 40 animals were randomly divided into 5 groups (n=8 in each group): (1) Normal control (Cont) (2) Diabetic group (DM); (3) Diabetic pretreated with caffeine group (PreCaf). (4) Diabetic acute caffeine treated group and (5) Diabetic chronic caffeine treatment group. Learning and memory were assessed by Morris-Water maze. The latency to reach the platform reflects the learning and memory of the tested animals. 

Recording from hippocampal slices showed a significant reduction in the NMDA-component of the fEPSPs responses compared to the control. The behavior study; all the DM-groups demonstrated defects in learning and memory tasks, only acutely administered caffeine (Ac Caf) could reverse the deteriorating effect of DM on the learning and memory functions.  Animals of this group showed lower latency values (72.4 ± 8.6 s) to reach the hidden platform in the water maze compared to the other diabetic groups (DM= 116.67 ± 3.33, Pre Caf= 101.8 ± 7.1, and Ch Caf= 94.13 ± 7.8) (ANOVA, p< 0.05). The performance of this group was not significantly different than the control animals. 

We concluded that the NAMD-receptor component of the fEPSP was significantly reduced in the STZ-induced DM. This resulted in deterioration in memory tasks. Acute administration of caffeine could reverse this defect. Pre-treatment of the mice with caffeine before the induction of DM may partially protect these animals from the cognitive- induced defects by the induced DM.

Biography:

Shamima Akter has her expertise in Nutritional Epidemiology. She is now working as a senior researcher in Department of Epidemiology and Prevention, National Center for Global Health and Medicine, Tokyo, Japan. Her publication covers epidemiological research on non-communicable diseases, especially type 2 diabetes and metabolic bio-markers. She published many papers on this field in prestigious international journal like BMJ, Diabetes Care, American Journal of Clinical Nutrition, Clinical Nutrition, and others. She also received best young investigator award in 13th International Conference on Endothelin.

Abstract:

Statement of the Problem: Women who have experienced intimate partnerviolence (IPV) are at greater risk for physical and mental health problems including posttraumatic stress disorder (PTSD) and alcohol dependency. On their own IPV, PTSD and alcohol dependency result   in significant personal, social and economic cost and the impact of all three may compound these costs. Researchers have reported that women with these experiences are more difficult to treat; many do not access treatment and those who do, frequently do not stay because of difficulty maintaining helping relationships. However, these women’s perspective has not been previously studied. The purpose of this study is to describe the experience of seeking help for alcohol dependency by women with PTSD and a history of IPV in the context in which it occurs. Methodology & Theoretical Orientation: An inter subjective ethnographic study using hermeneutic dialogue was utilized during participant observation, in- depth interviews and focus groups. An ecological framework was utilized to focus on the interaction between the counselors and the staff to understand this relationships and the context in which it occurs. Findings: The women in this study were very active help seekers. They encountered many gaps in continuity of care including discharge because of relapse. Although the treatment center was a warm, healing and spiritual place, the women left the center without treatment for their trauma needs   and many without any referral to address these outstanding issues. Conclusion & Significance: Women with alcohol dependence and PTSD with a history of IPV want help however the health and social services do not always recognize their calls for help or their symptoms of distress. Recommendations are made for treatment centers to become trauma- informed that would help this recognition.

Biography:

Dr Bashair Mussa is currently an Assistant Professor of Physiology (University of Sharjah, United Arab Emirates).  She graduated from the University of Melbourne (Australia) with a PhD in Neurophysiology and Pharmacology. She has an extensive experience in diabetes research and she characterized the neural pathways and receptors that are involved in the control of insulin secretion.  Currently she is a principal investigator of three projects that related to diabetes and Emirati patients.  Her current research focuses on the central control of pancreatic secretion, glucose homeostasis and diabetes.

Abstract:

Optimal glycemic control and weight management involve several approaches including nutrition recommendations and physical activity.  However, recent views have suggested that there are other factors including sleep deprivation and stress contribute to development of Type 2 diabetes mellitus (T2DM).  Therefore, the present study was designed to investigate the effects of a novel intervention on weight and glycemic control in Emirati patients with type 2 diabetes. 

The present study is a randomized controlled study.  27 Emirati patients with type 2 DM (18–60 years, BMI ≥ 25kg/m²) were included in the study; intervention group, n = 14 and control group, n = 13.  Heart rate variability was used for real-life and long-term assessments of sleep, stress and recovery.  The intervention group attended information session followed by an initial assessment of the stress and recovery levels, and sleep pattern and feedback sessions.  Action plans were created for each patient based on the outcomes of the initial assessment.  Follow-up procedures (Fig. 1).

The results have shown that the percent change in body weight was significantly greater (p < 0.05) in the intervention group (- 3.18%) compared to the control group (- 0.02 %).  The percent change in the BMI of the intervention group was - 4.50% whereas the control group exhibited less change in BMI (- 0.0003%, p < 0.05).  In addition, a significant reduction in HbA1C was observed in the intervention group (-5.3%) and an increase of 9.9% was observed in the control group (p < 0.01).  Moreover, stress levels were decreased in the intervention group (-2.2%) whereas the percent change in the stress levels in the control group was 25.3 %.  

The interventions that reduce the levels of stress, enhance the recovery levels and maintain healthy sleep habits play an important role in weight management and glycemic control in type 2 DM.

Biography:

Hamdiye Arda Sürücü has finished PHD education Internal Medicine Nursing at Dokuz Eylul University. Also she has got two master degreeses (Internal Medicine Nursing and Publich Health). Her PHD’s thesis is about Type 2 diabetes and Diabetes Self Management Education and the most of studies are about type 2 diabetes, empowerment, gestational diabetes mellitus and insulin. She has National diabetes certificate nursing. She has worked in the diabetes education center with diabetes as diabetes nursing for 10 years and have got a lot of article about diabetes. She has worked Nursing Department at Dicle University.

Abstract:

Introduction: Empowerment is defined as providing power or bringing in authority, the skill and competence to accomplish something and to grant permission. Empowerment consists of two processes as “process” and “outcome”. The objective of these two processes is development of potential of individual with diabetes at the first stage and maturation of this potential at the last stage.  There is a limited amount of research investigating the factors influential on empowerment.  Purpose: Examining the factors influential on empowerment in diabetes is thought to shed light on the planning and management of diabetes education. In addition we discuss how we can empowerment diabetes patient. The factors influential on empowerment in diabetes studies revealed that the number of diabetes-related symptoms, age, gender, educational background, disease duration and perceived family support, diabetes education, employment status are among the factors influential on empowerment. Consequently, in an attempt to empower individuals with diabetes through empowerment strategies in diabetes self-management education; “1. Instructor should not be the decision maker in decisions regarding diabetes management of patient, 2. Daily self-management decisions should be checked and their responsibilities should be confirmed, 3. Information should be provided for continuity of the situation of life-long decision making in diabetes, 4. Patients’ efforts should be facilitated in order to determine, implement and result of behavioural goals that are individually chosen, 5. Chances of social and emotional support should be created and individuals with diabetes should be included in a group which is created for problem-solving,

6. Instead of controlling patient, patient should be given responsibility in diabetes care, 7. Instructor should have a constant communication with its patients through telephone, mail etc., and 8. Instructor should make individual with diabetes feels important and valuable. 9. Diabetes literacy should be increased/encouraged and 10. Instructor should make individual with diabetes feels important and valuable. 

Biography:

Chetna  A Shamkuwar trained in Clinical Pharmacology by Indian Council of Medical Research, She has wide experience of teaching clinical pharmacology since last ten years. She is a recipient of travel fellowship grant by international union against tuberculosis and lung disease for immune-modulation research in tuberculosis. Her area of interest is research in rational drug use, adherence to treatments and its effects on clinical outcomes in chronic diseases. Her passion about clinical research and compassionate approach in patient care made her most sought   after health personnel in designing chronic diseases treatment protocols in the region.   

Abstract:

Statement of the Problem: The estimated number of diabetics in India was 62.4 million in 2011 projected to rise 101.2 million by 2030. Rational medication pattern and adherence to treatment are key components diabetes control. Study purpose is to evaluate medication pattern and assess  adherence to treatment. Methodology & Theoretical Orientation: Prospective, observational and questionnaire based study. Medication pattern evaluated from prescriptions and adherence assessed with Morisky Medication Adherence Scale. Findings: Total 194 prescriptions were studied. 96 (49.48%) and 98(50.51%) were male and female respectively. Majority  were above 60 years of age. Co-morbid conditions were found in 169 (87.11%) patients with Hypertension (74%), being more common. Patients were prescribed 1216 medications. The average number of drugs per prescription was 6.20. Oral hypoglycemic drugs were 22.69%. Commonly prescribed drugs were anti-hypertensive (15.70%), drugs for coronary artery disease (10.36%), Antibiotics, NSAID, PPI, Vitamins and Minerals (31.99%). High, medium and low adherence were observed in 47%, 38% and 15% of patients. Males (62%) adherence more than females in high adherence group. Conclusion & Significance: This study demonstrates the variability of drug utilization in diabetics. More than fifty percent patient have medium and low adherence which affects control of diabetes. Factors leading to poor adherence should be studied for better control of diabetes.

Biography:

Astrid Sugiantol is a 22-year-old Medical Doctor candidate with Bachelor of Medical Science degree from the University of Melbourne. She was nominated as one of the 300 young brightest scientists by Ministry of Education of UK in 2013. She was also the former Ambassador of the year for Harvard Project of International Relations in 2014 and also the only female representative of Indonesia for ASEAN Youth in 2014. She was previously involved in breast cancer stem cell research, before decided to focus on cellular based therapy research in 2015. She is interested in politics, international relations, psychology, and science. She wants to be a surgeon (and an astronaut) in the future. She loves reading books, watching movies, hiking, playing softball, diving, and traveling. She is a big fan of Leonardo DiCaprio, Justin Trudeau, Weeknd, and Quentin Tarantino

Abstract:

Introduction. The incidence of Type 1 Diabetes Mellitus (T1DM) has been increasing rapidly worldwide, while the current standard therapy – exogenous insulin supply – is considered unsustainable and highly associated with poor glycemic control that may lead to a life-threatening condition. On the other hand, cellular-based therapy including either islet cell or stem cell transplantation has been recently developed, making it pertinent to compare the effectiveness between the two alternative treatments. The aim of this systematic review is to compare the safety and effectiveness between islet cell transplantation and stem cell transplantation for future practice change. 

Methods. Literature search using two databases, PubMed and Ovid Medline, was conducted for primary studies published from January 2000 to November 2015. A quality assessment of identified studies were conducted using ARRIVE, NOS, and MINORS assessment tools. The comparison between treatments were done based on the mean values of insulin independence period and blood glycemic level of the subjects in the studies.

Results. In 15 out of 17 included studies, the average insulin-independent period in T1DM patient post-islet cell transplantation was proven to be four years longer compared to post-stem cell transplantation that could only achieve one year at most. The studies also found and support that islet cell transplantation has better blood glycemic control, observed through random blood glucose level ranges from 140mg/dL to 200mg/dL and c-peptide levels ranges from 0.3ng/ml to 4.5ng/ml which marks the presence of insulin production.  However, certain challenges – eg, donor shortage and poor engraftment – hinders the widespread application. The studies also revealed that stem cell transplantation differentiated into b-cell-like cells that produce insulin, glucagon, and somatostatin, as well as acting in glucose-stimulated manner, imitating the physiologic mechanism of b-cells, this is in fact considered as a major potential for future development. 
Conclusion. The current studies had proven a conclusive result in which islet transplantation has relatively higher effectiveness and better outcome compared to stem cell transplantation for treating T1DM patients.

Biography:

1 - Student at Faculty of Dentistry, Jember University, Jember, Indonesia
2 - Professor of Pathology Anatomy, Faculty of Dentistry, Jember University, Jember, Indonesia
3 - Lecturer of Biomedicine, Faculty of Dentistry, Jember University, Jember, Indonesia

Abstract:

Statement of the Problem: Hyperglycemia elevates the advanced glycation end product (AGEs) formation which induced complication after tooth extraction, such as endothelial dysfunction. Thymoquinone (Tq), the active compoud of black seeds (Nigella sativa L.), has been known to stimulates new blood vessels activity also for its anti-diabetic properties. The purpose of the study is to determine the effect of Tq towards socket new blood vessels formation process after extraction in diabetic-induced rats. Methodology & Theoretical Orientation: 27 male rats were injected STZ intravenously and rats with blood glucose level ≥250 mg/dl were divided into three groups (K, P1, P2). Rats were given aquadest (K), Tq (P1) and Metformin (P1). On 7^th day after treatment, its lower first left molar teeth was extracted. 3 samples from each group were sacrificed on 3^rd, 7^th, and 10^th day after axtraction. HE and Immunohistochemical staining was used to observe the new blood vessels formation. Conclusion & Significance: We found the lowest blood glucose in P1 group on 10^th day after extraction. The new blood vessels formation in P1 showed the progressive formation significantly compared to P2 and K group (p<0,05). We conclude that Tq treatment may improve the socket new blood vessels formation process and prevent the complication. 

Biography:

Prof. Md. Faruque Pathan is an eminent Endocrinologist and Diabetologist. He is the Head of the Department of Endocrinology at BIRDEM General Hospital, Dhaka, Bangladesh. Prof. MF Pathan has published several research articles and review articles including the South Asian consensus guidelines on various aspects of management of diabetes, and presented research papers at various national and international conferences.

Abstract:

 

 

Biography:

Dr. Kyung Yul Hur, is a Professor and Chief of General Surgery at Soonchunhyang University Hospital, Seoul, Korea.

He adopted laparoscopic TEP hernia repair procedure in year 2003, and bypass surgery in Korea in September 2009, which was the first metabolic surgery performed in Korea. Presently He is a pioneer of laparoscopic surgery society in Korea.

Concerning to the bariatric and metabolic surgery, Dr. Hur has a different basic concept compare to another surgeon in Korea. He considers that the surgery is merely a beginning of the treatment for type 2 DM thus the procedure should remain simple, safe and reversible. Recently, Dr. Hur invented a new modified procedure aiming better quality of life for patients with comparable to antidiabetic effectiveness of previous surgical procedure.

Abstract:

We have experience of laparoscopic single anastomosis gastric bypass for non-obese type 2 diabetic subject since 2009. There had been minor problems which led to patients having to undergo annoying discomfort frustrates its clinical application. To improve postoperative QoL, we modified our established procedure since December 2015.

Most symptoms or complaints are linked to the absence of pyloric sphincter function. To recover this function, the entire stomach including sphincter should be preserved. While preserving the pyloric sphincter, we completely removed the duodenal tissue from the distal end of the stomach. We carry out our procedure based on three principles strictly:

(1) Preservation of the pyloric ring

(2) Total duodenal exclusion

(3) The biliopancreatic limb should be more than 200 cm

Most importantly, duodenal mucosa should be removed. Remained duodenal mucosa is possible cause of recurrent hyperglycemia 6 months after surgery. Compensatory hypertrophy and unique pattern of epithelial regeneration of short cut end of jejunum is answer of enigma. More than 200㎝ of biliopancreatic limb is mandatory. Alimentary limb is not necessary in metabolic surgery, Mere existence of nutrients enough to stimulate enteroendocrine cell. In metabolic surgery, alimentary limb is functional segment. Single anastomosis between pyloric ring and small bowel does not make any problem. Postoperative sphincter function was excellent.

From December 2015 to date, a total 40 patients have undergone this procedure. Postoperative GIQOL is highly satisfactory, with no significant discomfort in most subjects, and some patients have equal quality with their preoperative GIQOL.

Nine patients who were followed up for more than 12 months after surgery showed no evidence of recurrence. The clinical course of glycemic control was equal to or better than that of previous surgery