Ijaola
Science Laboratory Technology Department
Nigeria
Title: Antidiabetic Effect of Ipomoea batatas in Normal and Alloxan-Induced diabetic rats
Biography
Biography: Ijaola
Abstract
The hypoglycemic effects of graded quantities (200mg/kg, 300 mg/kg and 400mg/kg/day) of Ipomoea batatas leaf extracts at a dose of once daily for fourteen days on the blood glucose level of 20 rats whose glucose level exceeded 200mg/dl after alloxan induction were studied. Qualitative and quantitative analysis of phytochemical ingredients of Ipomoea batatas leaf were also carried out. Data obtained were subjected to Analysis of variance (ANOVA) with probability set at p<0.05. The results showed that oral treatment with 2ml of 200 mg/kg/day of Ipomoea batatas aqueous extract did not produce significant (p>0.05) alterations in the blood glucose concentration level when compared with basal value. Also, there was no significant difference (p>0.05) in the sugar level of rats treated with 300mg/kg/day and 400mg/kg/day of the extracts but the hypoglycemic effect significantly differ (p<0.05) from non-diabetic and rats treated with oral administration of 200mg/kg/day of Ipomoea batatas extracts. The highest percentage blood sugar reductions of 69.67% was recorded in rats treated with 300 mg/kg/day, followed by 59.24%( 400mg/kg/day extract) while the least percentage sugar reduction of 52.18% was observed in 200mg/kg/day extract. The non-diabetic induced rats exhibited steady increase (8.03%) in their normal glucose level. It was revealed that alloxan induced rats treated with 200mg/kg/day, 300mg/kg/day and 400mg/kg/day sustained percentage weight loss of 48.91, 28.66 and 31.11 percent respectively compared with non-diabetic induced rats. The qualitative phytochemical screening investigation of Ipomoea batatas indicated the presence of alkaloids, flavonoids, tannins, saponins, steroids, phenol, anthraquinone, Phlobatannin, Glycosides and terpenoids. Also, quantitative phytochemical study revealed that saponin (6.21) was the highest phytochemical content followed by tannin (4.15) while Glycoside was the least (0.40). In conclusion, 300mg/kg/day of the extract produced the best hypoglycemic effect (69.67%) in diabetic induced rats.