Małgorzata Zakłos-Szyda
Lodz University of Technology
Poland
Title: Polyphenolic extracts from selected edible plants protect pancreatic βTC3 and hepatic HepG2 cells viability and function against oxidative stress in diabetes
Biography
Biography: Małgorzata Zakłos-Szyda
Abstract
Epidemiological data indicate that diabetes is one of the main health problems of the world. Type 2 diabetes (T2D) which is usually a result of wrong dietary habits and reduced physical activity, represents 85-95% of all diabetes cases and among other diet-related diseases is the major cause of deaths. The disease is mainly associated with irregularities in the insulin secretion, attenuated insulin sensitivity and pancreatic beta cells dysfunction caused by multiple stimuli including glucotoxicity, lipotoxicity, proinflammatory cytokines, endoplasmatic reticulum stress and oxidative stress. Those factors lead to increased level of blood glucose concentration after food intake. Since polyphenols possess multiple biological activities and constitute an important part in human diet, they have recently emerged as critical phytochemicals in type 2 diabetes prevention and treatment. This study investigates polyphenolic extracts obtained from selected edible plants, which were screened in terms of protective activity against oxidative stress induced by tert-butylhydroperoxide (t-BOOH) in βTC3 pancreatic and HepG2 hepatic cells. These cell lines are commonly used as model targets for antidiabetic drugs.
