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David Karasek

University Hospital Olomouc, Czech Republic

Title: Selected Adipokines In Patients With Type 2 Diabetes: Relationship To Markers Of Endothelial Dysfunction And Arterial Stiffness


Biography: David Karasek


Introduction: Adiponectin, adipocyte fatty acid-binding protein (A-FABP), fibroblast growth factor 21 (FGF-21), C1q/TNF-related protein 9 (CTRP9) and allograft inflammatory factor-1 (AIF-1) differently contribute to oxidative stress, chronic inflammation, insulin resistance and vascular damage. The aim was to compare their levels in patients with type 2 diabetes and in healthy controls and to determine their relationship to markers of endothelial dysfunction and arterial stiffness.

 Methods: 54 patients with type 2 diabetes (32 men, 22 women) and 21 healthy controls (8 men, 13 women) were included in the study. Adipokines, lipids, anthropological parameters, indicators of insulin resistance and also soluble markers of endothelial dysfunction - von Willebrand factor (vWF), plasminogen activator inhibitor-1 (PAI-1) and tissue plasminogen activator (t-PA) were measured. Augmentation index (AI) and pulse wave velocity PVW measured by SphygmoCor served as markers of arterial stiffness.

 Results: Type 2 diabetics had significantly higher levels of A-FABP [50.0 (38.1-68.6) versus 28.6 (23.6-32.9) mg/l, p<0.001], vWF [133.1 (110.7-163.2) versus 98.5 (84.4-125.0)%, p<0.01] and PAI [78.1 (41.2-106.5) versus 36.9 (27.5-41.9) ng/ml, p<0.001] and lower levels of adiponectin [5.9 (4.3-9.0) versus 11.3 (8.7-14.8) mg/l, p<0.001] compared to healthy controls. Differences in other adipokines were not statistically significant. Adiponectin correlated negatively with vWF levels (r=-0.29, p<0.05) and PAI-1 (r=-0.35, p<0.01), A-FABP positively with vWF (r=0.45, p<0.01) PAI-1 (r=0.46, p<0.01) and augmentation index (r=0.39, p<0.01). The levels of FGF-21 correlated only with PAI-1 (r=0.27, p<0.05).

Conclusion: Patients with type 2 diabetes have significantly higher levels of A-FABP and lower levels of adiponectin. These adipokines correlate with markers of vascular damage and may interfere with the cardiovascular risk of these individuals.

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