Meet Inspiring Speakers and Experts at our 3000+ Global Conference Series LLC LTD Events with over 1000+ Conferences, 1000+ Symposiums
and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.

Explore and learn more about Conference Series LLC LTD : World’s leading Event Organizer

Back

27th European Diabetes Congress

Rome, Italy

Yoshihisa Sugimura

Yoshihisa Sugimura

Fujita Health University | Japan

Title: Rabphilin-3A as a targeted autoantigen in lymphocytic infundibuloneurohypophysitis

Biography

Biography: Yoshihisa Sugimura

Abstract

Central diabetes insipidus (CDI) can be caused by several diseases, but in about half of the patients the etiological diagnosis remains unknown. Lymphocytic infundibulo-neurohypophysitis (LINH) is an increasingly recognized entity among idiopathic CDI; however, the differential diagnosis from other pituitary diseases including tumors can be difficult due to similar clinical manifestations. The definite diagnosis of LINH requires invasive pituitary biopsy. The study was designed to identify the autoantigen(s) in LINH and thus develop a diagnostic test based on serum autoantibodies. Rabphilin-3A proved the most
diagnostically useful autoantigen. Anti-rabphilin-3A antibodies were detected in 22 of the 29 (76%) patients (including 4 of the 4 biopsy-proven samples) with LINH. In contrast, these antibodies were absent in patients with biopsy-proven sellar/ suprasellar masses without lymphocytic hypophysitis (n=34), including 18 patients with CDI. Rabphilin-3A was expressed in posterior pituitary and hypothalamic vasopressin neurons but not anterior pituitary. In conclusion, these results suggest that rabphilin-3A is a major autoantigen in LINH. Autoantibodies to rabphilin-3A may serve as a biomarker for the diagnosis of LINH, and be useful for the differential diagnosis in patients with CDI.