Biography:

Rachita Nanda is currently working as associate professor at Department of biochemistry,AIIMS, Chattisgarh,India.She is also been interested in doing her researches in field of Diabetes and Endocrinology

Abstract:

Molecular chaperones play a role in folding of nascent polypeptides into their biologically active structures. Also known as heat shock proteins(HSP), they respond to a wide variety of stress protecting the cell and their organelles against many chronically and acutely stressful conditions. Activation of HSP results in stress tolerance and also protection against stress induced molecular damage. Obesity which is associated with diabetes is linked to a state of chronic inflammation. Therein occurs release of various cytokines which lead to insulin resistance. With an ever continuing rise of diabetes which is snowballing into an epidemic, chaperone proteins have been implicated in blocking inflammation and thus in the treatment of insulin resistance and obesity associated with type 2 diabetes mellitus.

Biography:

Professor Nandakumaran Obtained his Doctorate Degree (PhD) in Reproductive Physiology from University of Paris VI, France in 1979. Worked for 4 Years as Research Consultamt in Biochemcial Pharmacology at St Vincent de Paul Hospital, Paris, France , Working currenlty as Professor of Obstetrics and Gynecology at Kuwait Medical Faculty, DrNandakumaran specilaizes in maternal-fetal exchange of nutrients and drugs in humans and animals in normal and disease states and has publsihed nearly 90 research papers in International Scientific Journals as well as in International Conferences

Abstract:

Diabetes Mellitus in pregnancy is well known to be associated with increased maternal as well as neonatal mortality and morbidity. Altered disposition of essential trace elements and anti-oxidant function have been implicated in genesis of the disease as well as in increasing incidence of congenital malformations in the diabetic state as well. Previous studies in our laboratory have shown altered maternal-fetal disposition of some essential trace elements such Cu.Fe, Mo, Se and Zn in both insulin-dependent as well as gestational diabetic pregnancies. However there have been no reports to date on maternal-fetal transport of essential trace elements such as Cr, Mn and V in diabetic pregnancies in humans or experimental animals. Here we report for the first time in the literature maternal-fetal transport kinetics of the above mentioned trace elements in control and normoglycemic state and have explored the possible effect hyperglycemic diabetic state on the transport kinetics of the above elements in diabetic model human placental lobule in vitro, using perfusion of isolated human placental lobules in vitro. This perfusion method has been used extensively by us in assessing maternal-fetal transport of a variety of drugs and nutrients, including essential trace elements in control as well as diabetic pregnancies as well. Our studies show that hyperglycemia state alters maternal-fetal transport kinetics of above trace elements in vitro which could have nefarious fetal effects on the baby in the womb in hyperglycemic diabetes states.

Biography:

Elahe Elhami is currently a Pharma D student at Visveswarapura Institute of Pharmaceutical Sciences. Her area of interest is Basic and Applied Research on Cancer.

Abstract:

Background: Foot infections are a common and serious problem in persons with diabetes. Diabetic foot infections (DFIs) typically begin in a wound, most often a neuropathic ulceration. While all wounds are colonized with microorganisms, the presence of infection is defined by ≥2 classic findings of inflammation or purulence. Infections are then classified into mild (superficial and limited in size and depth), moderate (deeper or more extensive), or severe. Uninfected wounds do not require antibiotic therapy, infected wounds do. Empiric antibiotic regimens must be based on available clinical and epidemiologic data, but definitive therapy should be based on cultures of infected tissue. Objective of the study is to investigate the antimicrobial susceptibility pattern of microbes in DFIs. Inclusion criteria: All diabetic patients admitted to surgery unit with foot ulcer.
Exclusion criteria: All patients referred from other unit like medicine or orthopaedics or any other speciality will be excluded.
Methodology: We used the patient database to conduct a retrospective observational study of hospitalized patients with diabetic foot infections. Patient record system, which contains patient demographics, diagnoses, diagnostic studies, treatments received and patient outcomes. With this information it is possible to examine the antibiotic regimens of large numbers of diabetic patients with foot infections

Biography:

G. Suresh Kumar has completed his PhD at the age of 28 years from University of Mysuru and Postdoctoral studies from Daegu University, South Korea and McMaster University, Canada respectively. He is a Scientist at CFTRI, Mysuru working in the area of Biochemistry and specialization in obesity, diabetes and diabetic nephropathy. He has published more than 20 papers in various reputed national and international journals.

Abstract:

Diabetic nephropathy (DN) is the most serious microvascular complication of diabetes. Involvement of sterol regulatory binding protein (SREBP1) in the development of DN may trigger the expression of TGF-, which enhances the accumulation of extracellular matrix in diabetic kidney. Oryzanol Concentrate (OC) shown to have hypolipidemic property has been evaluated for DN complications in the current study. Animals were grouped into starch fed; High fat fed and treated control (SFC, HFC, OFC 0.1 and 0.3%) as well as respective diabetics (SFD, HFD, OFD 0.1 and 0.3%). Diabetes was induced by injecting STZ to animals. Lipid profile in the HFD groups was altered significantly when compared to SFD group and was ameliorated by oryzanol concentrate treated groups in dose dependent manner. Increased glomerular filtration rate (GFR) and kidney weight in HFD groups were reduced with OC (0.1 &0.3%) treatment by 1.09 and 1.3 fold. PAS and Immunohistochemistry of the sections showed the accumulation of glycoprotein and collagen (IV) in HFD whose intensity was reduced with OC groups. Expression of TGF-β gene was corroborated with kidney sections of HFD (2.7 fold) and in treated groups, which down regulated by 1.3 and 1.36 fold, where the expression in SFD was 1.6 fold lesser than the HFD. Content of fat in kidney was higher in HFD when compared to SFD group and was reduced by OC. In the current study oryzanol concentrate had positive effect in reducing DN and use of such an ingredient in the preparation of food may be recommended for diabetics.

Biography:

Dr. Vaishali has completed his PhD in pharmaceutical science at the age of 37 years from Sardar Patel University at Gujarat. She is the professor and head of pharmaceutics department at anand pharmacy college. She has more than 15 years of teching experience and reserch experience . She has published more than 40 papers in reputed journals and also reciepient of two national level awards for best innovative reserch project by SRISTI and 3M .

Abstract:

Type II diabetes is a lifelong (chronic) disease in which there are high levels of sugar (glucose) in the blood. Currently, India leads the world with the largest number of diabetic patients and this is expected to further rise in the coming years. The combination therapy is used to provide an optimal level of glycerin control over non-insulin dependent diabetes mellitus (NIDDM) patient. One of the extended released formulation available in market, TRIEXER contains three oral anti-hyperglycaemic drugs namely glimepiride, pioglitazone hydrochloride and metformin hydrochloride in the management of type II diabetes (NIDDM). The disadvantages of Pioglitazone hydrochloride are weight gain, slow onset of action, liver toxicity etc. Clinical trial data shows that Sitagliptin 100 mg once daily significantly improved glycaemic control and beta-cell function in patients with type II diabetes who had inadequate glycaemic control with glimepiride or glimepiride plus metformin therapy In the light of above reserch, the objective of the present project work is to develop fixed dose triple combination of antidiabetic drugs wherein Sitagliptine and Glimepride are as immediate release form and Metformin is as extended release (ER) form. Primarily, formulation optimization of metformin was done for extended release by factorial design. In the second set of experiments, design space for process parameters ( inlet, outlet temp, atomizing pressure and flow rate) and its influence on coated tablet characteristics was developed. Result of above study was revealed that clinically relevant newer fix dose combination formulation successfully design by implementing principal of Quality By design.

Biography:

Sayantan Nath has completed his M.Sc. at the age of 25 years from Dept. of Biotechnology, Assam University,Silchar, India and is currently pursuing doctoral research under Dr. Yashmin Choudhury at Dept. of Biotechnology, Assam University, Silchar. He has published 3 papers in reputed journals and has 1 book chapter.

Abstract:

Diabetes mellitus (DM) is one of the most rampant metabolic disorders characterized by hyperglycemia with altered carbohydrate, lipid and protein metabolism. DM is associated with the production of reactive oxygen species (ROS) thereby generating oxidative damage in different tissues. 5' adenosine monophosphate-activated protein kinase (AMPK) is a serine-threonine kinase found in all eukaryotes that regulates glucose and lipid metabolism and its dysregulation results in the development of DM. The present study demonstrates the novel observation that activation of AMPK in type I diabetic mice is gender- and tissue-specific. The study involved the use of a type 1 diabetic mouse model in both male and female Swiss albino mice by administering alloxan monohydrate (150 mg kg-1 body weight) injection intraperitoneally (i.p). Spectrophotometric analysis of DM associated oxidative stress parameters (viz. lipid peroxidation and protein carbonylation) and slot blotting of phospho-AMPK were performed using anti-phospho AMPK antibody. There was a pronounced increase in oxidative stress parameters in heart, kidney and liver tissue in male alloxan-induced diabetic mice in comparison to female. Lipid profiling also showed a steep increase in total cholesterol, triglyceride, low-density lipoproteins (LDL) and very low-density lipoproteins (LDL) with decrease in high-density lipoproteins (HDL) in both male and female DM mice. With increase in oxidative stress parameters, mean intensities of phospho-AMPK levels in heart, kidney and liver tissues of male DM mice displayed a significant decrease in comparison to that of control mice. However, in female DM mice there was an increase of phospho-AMPK level in heart tissue with respect to controls, while a decreased phospho-AMPK level was noticed for kidney and liver tissues with respect to controls.

Biography:

Sayantan Nath has completed his M.Sc. at the age of 25 years from Dept. of Biotechnology, Assam University,Silchar, India and is currently pursuing doctoral research under Dr. Yashmin Choudhury at Dept. of Biotechnology, Assam University, Silchar. He has published 3 papers in reputed journals and has 1 book chapter.

Abstract:

Diabetes mellitus (DM) is one of the most rampant metabolic disorders characterized by hyperglycemia with altered carbohydrate, lipid and protein metabolism. DM is associated with the production of reactive oxygen species (ROS) thereby generating oxidative damage in different tissues. 5' adenosine monophosphate-activated protein kinase (AMPK) is a serine-threonine kinase found in all eukaryotes that regulates glucose and lipid metabolism and its dysregulation results in the development of DM. The present study demonstrates the novel observation that activation of AMPK in type I diabetic mice is gender- and tissue-specific. The study involved the use of a type 1 diabetic mouse model in both male and female Swiss albino mice by administering alloxan monohydrate (150 mg kg-1 body weight) injection intraperitoneally (i.p). Spectrophotometric analysis of DM associated oxidative stress parameters (viz. lipid peroxidation and protein carbonylation) and slot blotting of phospho-AMPK were performed using anti-phospho AMPK antibody. There was a pronounced increase in oxidative stress parameters in heart, kidney and liver tissue in male alloxan-induced diabetic mice in comparison to female. Lipid profiling also showed a steep increase in total cholesterol, triglyceride, low-density lipoproteins (LDL) and very low-density lipoproteins (LDL) with decrease in high-density lipoproteins (HDL) in both male and female DM mice. With increase in oxidative stress parameters, mean intensities of phospho-AMPK levels in heart, kidney and liver tissues of male DM mice displayed a significant decrease in comparison to that of control mice. However, in female DM mice there was an increase of phospho-AMPK level in heart tissue with respect to controls, while a decreased phospho-AMPK level was noticed for kidney and liver tissues with respect to controls.

Biography:

Purabi Sarkar is currently pursuing her Ph.D in Biotechnology from Gauhati University under the supervision of Dr. Sofia Banu. She has completed her Masters in Biotechnology from Bangalore University and Post Graduate Diploma in Advanced Clinical Research from ICRI, Bangalore. She has worked as Research Trainee at R & D Centre, Indian Immunologicals Ltd, Hyderabad under the DBT-BCIL training program. She has published three article in International Journals (includes Elsevier publications) and 2 popular paper articles. She has presented her work in two international conferences and two national conferences.

Abstract:

Type 2 diabetes (T2D) is the most prevalent and serious metabolic disease all over the world. Oxidative stress caused by increased generation of reactive oxygen species (ROS) under hyperglycemia may contribute to the development of T2D. Therefore, cells have antioxidant networks to scavenge excessively produced ROS and antioxidants neutralize these ROS and decrease oxidative stress. The present study was designed to evaluate and compare the effect on oxidative stress pathway genes upon supplementation of antioxidants Resveratrol and Estragole in L6 cell line to combat diabetic stress conditions by qPCR system. In this study the results show up- regulation of GST and SOD gene in L6 cell lines treated with Antioxidant alone ,HNE+Antioxidant, Antioxidant+Insulin and HNE+Antioxidant+Insulin combinations. When compared with the control, Resveratrol+ Insulin treatment shows 2.48 folds up-regulation in GST gene and 2.28 folds up-regulation in SOD gene as compared to other treatment set. Similarly, Estragole also up-regulate GST expression by 2.15 folds and SOD expression by 2.34 folds in the Estragole+Insulin treatment set. In case of GPx gene, Estragole up-regulate by 0.60 folds in cells treated only with Estragole and Resveratrol show down-regulation of 2.04 folds in the HNE+Antioxidant treatment set. Whereas, CAT gene down-regulate by 3.22 folds in HNE+Antioxidant+Insulin treatment set for Estragole and Resveratrol up-regulate by 0.94 folds in only Resveratrol treatment. The study demonstrates that antioxidants Resveratrol and Estragole may be effective in combating ROS scavenging in patients with T2D. We have found Insulin alone can combat diabetes but its combination with dietary antioxidant perform better and are more effective.

Biography:

Abstract:

The incidence of type 2 diabetes has gained its identity as the most prevalent chronic disease worldwide with unavoidable burden to the healthcare system and the society. Despite the advancement in modern medicine practice the clinical effect and outcomes are unenviable which affect health related quality of life. The complication in its management is due to excessive use of medications which has increased enormously in the past time. Furthermore, the existence of co morbidity such as hypertension, CAD, obesity may increase the number of medications which may become appropriate therapy. On the top, the benefits of medications always co-exist with potential suffering, even when the right drug is prescribed and at recommended doses. With this context, the consequence of drug-drug interaction may range from serious to life-threatening clinical condition. Moreover, the inability to differentiate drug-induced manifestation such as hypoglycemia may result in reduction or deletion of dose or increment if hyperglycemia persist, which in turn increases the risk of interactions. The true incidence of drug interactions is unknown as many are not reported, even if reported are not documented as a drug interaction, but rather consider as an adverse drug reaction. Although drug interactions for a few selected drugs are well known, we often ignore the considerable evidence that potential interactions exist in many of the drug therapy prescribed today. In this review we focus on the most frequent drug-drug interactions, in type 2 diabetic patients with co-morbidities, while considering physiological, genetical and environmental factors in diverse patients.

Biography:

Abstract:

Due to the constant monitoring of the patient with diabetes 2, the carers themselves may show physical and emotional exhaustion ,may become vulnerable to physical ailments like blood pressure, increased risk of stroke etc. and psychological problems. A survey of hospitals showed that approximately hundred patients with diabetes type 2 are visiting the hospitals in Chandigarh and Mohali on a single day of outpatient department .Investigation was carried out on spouses of 100 patients with diabetes2 and of hundred without any chronic ailment( with equal number of male and female spouses in each group), in the age range of 35-40years , who have been married for approximately three to four years and have at least one child. Marital satisfaction inventory (Synder, 1979),Compassion fatigue (Figley, 1995)and WHO Quality of life (WHO, 1996)were administered to the subjects. Besides, a semi structured interview schedule was used for obtaining other related demographic information. Descriptive statistics , t-ratio , correlational analysis and multiple regression analysis was applied. Compassion fatigue came out to be significant predictor of quality of life and marital satisfaction in female spouses of patients . Female spouses were lower on quality of life and marital satisfaction as compared male spouses of patients. Significant differences emerged on compassion fatigue, quality of life and marital satisfaction in spouses of patients with diabetes and spouses of subjects without any chronicROHIN VINAYAK- Student of second year of MBBS, he has been interested in conducting investigations dealing with medical conditions. As the youngest researcher , he presented a research paper at 93rd Canadian Chemistry Conference held in 2010 at Toronto, Canada. He is interested in carrying out research on psychological impact on the caregivers of patients with life debilitating ailments. He has published a research paper (as co author ) in a reputed journal. ailment.

Biography:

Justin Rayappa A, He did UG and M.Phil Zoology at Presidency College and M.Sc Zoology from Loyola College, Chennai. At present pursuing Part time PhD under the guidance of Dr. Mazher Sultana, Rtd. Prof and Head, presidency College Chennai through AMET University, ECR Chennai. Working as PG Assistant at Dominic Savio Hr Sec School, Chennai

Abstract:

The practice of placing a small tobacco or chewing tobacco in the oral cavity and leaving it in place for extended period of time appears to be finding its way onto middle school, high school and college campuses as socially acceptable habits. Numerous reports in the literature have, described oral changes that appears to be associated with the use of smokeless tobacco in the adults. Such information is not available in the teenagers/adolescents/ lower age groups residents of SS Puram and SVM Nagar located in the Otteri area of North Chennai, Tamilnadu. A survey (Questionnaire) was used to collect information about students’ smokeless tobacco use, students’ current knowledge and the impact of smokeless tobacco on health. It was observed that smokeless tobacco habit is prevalent in males than female. Most common age to start smokeless tobacco was found as 12 and MAWA, HANS and Gutkha was most commonly used chewing material in Otteri area, consumed for more than five times a day by individuals with habit. Use of smokeless tobacco was appeared to cause a greater variety and severity of habit and tissue changes among the users than individuals without the tobacco habit.

Biography:

Mohammed Suhail Hussain M, M.Sc., Biotechnology (2008 – University of Madras) and Completed his M.Phil. Advanced Biochemistry (2012 – Thiruvalluvar University). He is worked as Assistant Prof. in the department of Environmental engineering at K.A.R Polytechnic College, Ambur. Later he joined as Product promoter and later he became as manager in immuno division, CPC Diagnostic company. Presently he is pursuing his doctorate degree under the guidance of Dr. Mazher Sultana at Marine Biotechnology, AMET University, Chennai.

Abstract:

Diabetics is a serious disorder it leads to various micro and macro vascular complications. The main purpose of the study is to find out the most common complications and the difference of WBC among the workers of match and fire workers of sivakasi area Tamilnadu, India. For this study 173 (99 male and 74 female) Diabetic workers having diabetic complications were selected and their Behavioral and socio-economic data were collected by individually asked questions and clinical analysis done on their blood samples. Cardiovascular (29%) and Neuropathy (28%) were present high among the workers. Total count was more in cardio vascular workers. At the same time Neutrophil count was high and lymphocyte count was low in cardiovascular complications compared to other complications.

Biography:

Shilpa Paranjape has completed her MD(Medicine), MBBS with specialization in field of medicine.Presently she is working as senior technical officer at Industrial Research Institute’s National Environmental Engineering Institute, India

Abstract:

We are facing challenge of increasing elderly population with diabetes and prediabetes. The problems that are specific to elderly diabetics include : (i) Non responsive bacterial and fungal infections, (ii) Hypoglycemia, (iii) Frequent falls, fatigue, dizziness, (iv) Increased Incontinence and bladder dysfunction, (v) Electrolyte imbalance and Nutritional deficiencies, (vi) Hyperosmolar Non-Ketotic Coma, (vii) Frozen Shoulder, (viii) Cardiovascular events,(ix) Renal decompensation, (x) Hepatic Dysfunction, (xi) Depression, Anxiety, (xii) Neurological complications,etc to name a few. All these factors exert serious impact on quality of life of the patient as well as aggravated healthcare burden and cost. The goal of treatment differs in elderly. A delicate balance between Hypoglycemia and Hyperglycemia has to be maintained. Medical Nutrition therapy and Exercise therapy have to be Individualised keeping in view the functional and physical capacity of the person as well as their socio-economic status. Home monitoring of Blood Glucose and Blood Pressure should be advocated as frequent hospital visits may not be possible for elderly people. Optimal use of modern technology for communication should be utilised for monitoring the patient. Drug therapy should be designed considering the co morbidities, side effects of drugs and drug-drug interaction between various drugs. Drugs with multiple effects and combination therapies can be advocated to reduce the pill burden. Thus, though care of elderly diabetic is a challenging task, it can be efficiently handled with team effort of qualified physician, diabetes educator, nutritionist, supportive family member, attendant and patient. Individualisation of therapy is key to good management of an elderly diabetic.

Biography:

Purbajit Chetia has completed his M.Pharm in 2012 from Sikkim University and enrolled PhD in Assam Down Town University, Guwahati, Assam. Currently he is working as a Assistant Professor in the department of pharmaceutical science in Assam Down Town University. He is having a few research publication in reputed journals.

Abstract:

Diabetes mellitus is a metabolic disorder characterized by hyperglycaemia that results from defects in insulin secretion and action or both. The presence of DM employs increased risk of many complications such as cardio vascular disease, coronary artery disease, stroke, neuropathy, renal failure, renal failure, retinopathy etc. This study concentrates on the experimental investigation of the antidiabetic activity of the leaves of Plantago major Linn (Family: Plantaginaceae). Diabetes was induced in Wister rats used for this study by streptozotocin. The methanolic extracts of leaves of Plantago major were administered orally (100 and 200 mg/kg, for 15 days). Hypoglycemic effects, oral glucose tolerance test, change in body weight and lipid profile of diabetic rat treated with methanolic extracts were determined and compared with normal, diabetic control and standard drug treated rats. Histological examination during 15 days of treatment was also carried out. Methanolic extract (200 mg/kg) produced a significant reduction in fasting blood glucose level in streptozotocin-induced diabetic rats. Significant differences were also observed in urine glucose level, oral glucose tolerance test, serum lipid profile and body weight of methanolic extract treated diabetic rats, when compared with diabetic, normal and standard drug treated rats.

Biography:

Koushik Nandan Dutta has completed his M.Pharm in 2013 from Uttarakhand technical university,Dehradun and enrolled PhD in Assam Down Town University, Guwahati, Assam.He has completed 1 year project at Defence Reserch laboratory, Tezpur Assam. Currently he is working as a Assistant Professor in the department of pharmaceutical science in Assam Down Town University. He has published eight publication in reputed journals

Abstract:

Diabetes mellitus (DM) is a chronic disease caused by inherited or acquired deficiency in production of insulin by the pancreas, or by the ineffectiveness of the insulin produced. India has today become the diabetic capital of the worldwide over 20 million diabetes and this number is set to increase to 57 million by 2025.Decreased physical activity,increasing obesity,stress and changes in food consumption is the main reason for causing Diabetes mellitus.Though different types of oral hypoglycemic agents are available along with insulin for the treatment of diabetes,there is an increase demand by patients to use natural products with antidiabetic activity. The present study was carried out to investigate the antidiabetic potential of ethanolic extract of the leaves of Sonchus asper (Family- Asteraceae) and Sonchus arvensis (Family-Asteraceae).Oral administration of ethanolic extract in the doses of 100, 150 & 200 mg/kg body weight to white Wistar rats significantly reduced their blood sugar level in alloxon induced diabetic rats under acute and sub-acute studies.The results showed that the ethanolic extract doses of 200mg/kg b.wt has significant antihyperglycemic effect in experimental model of diabetes mellitus. Based on the results, it can be reasonably concluded that both sonchus species has antidiabetic activity. This study also becomes a valuable reference for further research.

Biography:

Maria Letizia Iabichella is a medical doctor graduated at the University of Pisa (Italy) and specialized in angiology. She is interested in clinical and home wound care management and in microvascular research by non invasive diagnostic methods. She is currently a lecturer at the University of Siena (Italy) and author of several articles. She has developed a new method to treat vascular, diabetic and Buruli ulcer with ozone. She founded Helios Med Onlus, International Health Cooperation, in 2011 aimed at training staff to perform social and health activities and sharing wound care know how through missions abroad.

Abstract:

The efficacy of the treatment with Hyperoil (mixture of Hypericum perforatum flowers extract and Azadirachta indica oil) in advanced ulcerated diabetic, vascular and neuropatic feet was described in a previous reports. Several surprisingly successful outcomes for infection damaged diabetic foot, without prior use of surgical procedure, demonstrated the great potential of the Hyperoil. In fact, the effective use of treatment with Hyperoil in patients with foot diabetic lesions was proved in a case series study. Current research lines in regenerative medicine focus on the creation of scaffolds with specific functionalities and structurally similar to the fibrous component of the Extra-Cellular Matrix, thus providing a biomimetic environment for cellular growth. The use of electrospun scaffolds made by Poli(L-lactic acid, PLLA) functionalized with Hyperoil, having anti-infective properties, was recently demonstrated by using S. aureus, P. aeruginosa and K. ozaenae AM strains. In our preliminary observations, the scaffold functionalized with Hyperoil was applied directly in cleaned skin ulcers after debridment, showing also anti-inflammatory and tissue regeneration properties without perilesional damage. In particular, the biomimetic structure of the PLLA mat remarkably improves the tissue repair efficacy of Hyperoil used as regenerative skin graft easing wound healing time, avoiding surgical procedures in operating room and high costs for hospedalization. The outcome of the cooperation between regenerative medicine and tissue engineering fields lead to the development of scaffolds functionalized with Hyperoil which might be used use in extensive skin tissue loss like Buruli ulcer and burns due to their bacteriostatic, anti-flammatory and regenerative properties.

Biography:

Dr. R. Dhananjayan has completed his postgraduate in Medical Biochemistry (Faculty of Medicine) from PES Institute of Medical Sciences & Research, Andra Pradesh and Ph.D. in Medical Biochemistry (Faculty of Medicine) from Nizam’s Institute of Medical Sciences (NIMS), Hyderabad, Telangana. He has been awarded the Young Scientist Award-2008 and has won fellowship awards from Association of Clinical Biochemists of India. He has attended may National / International Conferences and published many scientific papers in National / International Journals. He is serving as a Faculty for MBBS, BDS, MDS and other health science courses for more than 14 years.

Abstract:

Functional polymorphisms in genes regulating one-carbon metabolism and deficiency of micronutrients such as folate, vit-B12, vit-B6 etc., perturbate one-carbon metabolism. Hence they are associated with elevated plasma homocysteine (HCY) and decreased functional folate, S-adenosyl methionine (SAM) and glutathione (GSH). Elevated HCY acts as pro-oxidant and found to generate free radicals by auto-oxidation, inducing lipid peroxidation, causes endothelial cell damage and also perturbing hemostasis. Decreased levels of folate are associated with defective synthesis of purines and uracil misincorporation in DNA. Decreased SAM with increased S-adenosylhomocysteine (SAH) blocks methyltransferases, leading to decreased cellular methylation and is associated with altered gene expression. The above events are likely to lead atherosclerosis and arterial thrombosis. Several SNPs were reported in genes regulating the one-carbon metabolic pathway interfere with the uptake of folate, folate carrier, DNA synthesis, synthesis of methyltetrahydrofolate, remethylation of HCY and reductive methylation of cobalamin. Among different polymorphisms of one-carbon metabolism, i.e., glutamate carboxypeptidase II (GCPII C1561T), reduced folate carrier 1 (RFC G80A), serine hydroxyl methyl transferase 1 (cSHMT C1420T), thymidylate synthase (TYMS 5’UTR) 28bp tandem repeat, methylenetetrahydrofolate reductase (MTHFR C677T) and 5-methyltetrahydrofolate homocysteine S-methyl transferase (MTR A2756G), the extensively studied polymorphisms in CAD are GCPII C1561T, MTHFR C677T and MTR A2756G. MTHFR C677T has been observed to be associated with independent risk for CAD in the subjects with low folate status. The increased oxidative stress is one of the main factors in etiology and complications of diabetes mellitus (DM). GSH is the major cellular antioxidant, detoxifies ROS, reduces peroxides and detoxifies multiple compounds through glutathione-S-transferase (GST) conjunction. GSTs defend cells against a wide variety of toxic insults from chemicals, metabolites and oxidative stress. An important condition affecting GST expression is oxidative stress, usually observed in DM. Folate and its metabolites play an important role in the synthesis, repair and methylation of DNA and hence any aberration in this metabolic pathway may lead to hyperhomocysteinemia which might contribute to etiology of CAD. Xenobiotic metabolism is the principle pathway that scavenges lipophilic xenobiotic agents and certain endogenous metabolites. Any alteration in this metabolic pathway prevents scavenging and increase reactive intermediates that have the potential of oxidative damage.

Biography:

Dr. Ravinder Singh is currently the Director of the Endocrinology Laboratory at the Mayo Clinic. One of his areas of expertise is application of liquid chromatography tandem mass spectrometric (LC-MS/MS) to clinical laboratory analysis. Many of the methods which he has developed are now considered reference methods, and have subsequently been utilized for method standardization efforts. As a result, the clinical diagnosis of Diabetes, Cushing’s disease, pheochromocytoma and congenital adrenal hyperplasia have been improved. He has published his work on originally developed methods including such analytes as cortisol, synthetic corticosteroids, metanephrines, estradiol, vitamin D, and urine albumin amongst others. Dr. Singh is also the Co-PI of 3 grants. He is Co-director of the ICL lab which supports the Human research protocols. He was recently granted a Novel methodology CTSA award for “Development of Robust LC-MS/MS Based Methods for the Absolute Quantification of Proteins and Peptides.” And he was recently awarded AACC Outstanding Speaker Award, as well as MSACL Leadership Award for Mass Spectometry Applications to the clinical lab.

Abstract:

The quality and standardization of HbA1c methods in the clinical laboratories will be discussed. The differences in various methods for mesuring HbA1c will be highlighted. The gold standard methodolgy and challenges in standardization of the testing will be presented. Interferences and specificty related to various Insulin assays will also be discussed. The quality of the POCT for glucose in real life will also be highlighted. How use of artificial pancreas will impact the management of diabetes will be part of the discussion as well.

Biography:

I am Lavanya v completed M-Tech dept of Processing and food engineering at the age of 24 years from College of Agricultural Engineering, University of Agricultural Sciences, Raichur, Karnataka, India. Now i am working as a Assistant Professor(contractual), Dept. of Dairy Engineering, Dairy Science College, Hebbal,Banglore, Karnataka(INDIA). I was published 4 papers in reputed journals and more than 10 Abstract in conference.

Abstract:

Fruits and vegetables are the abundant sources of bioactive compounds such as carotinoids, phenols, lignans, saponine etc. Bioactive compounds reacts in human body that may promote good health and effective in prevention of cancer, heart disease, and other chronic diseases. Nowadays, the demand for natural bioactive compounds is increasing due to their use in the functional food industries as well as in pharmaceutical industries. Plants produce a broad range of active compounds that usually exist inside cellular structures of plants. Bioactive compounds can be defined as the secondary plant metabolites eliciting pharmacological effect in man and animals. Compounds synthesized by plants that have the potential to be used by humans for a variety of applications. Nowadays, the demand for natural bioactive compounds is increasing due to their use in the functional food industry. Natural components from plants and other organisms are being used as: anti-oxidant, anti-microbial, anti-hypertensive, anti-cancer etc. It is also being used as additives and food supplements in food industry. Bioactive compounds have actions in the body that may promote good health. They are being studied in the prevention of cancer, heart disease, and other diseases. Examples of bioactive compounds include lycopene, resveratrol, lignan, tannins, and indoles. These active compounds or secondary metabolites which play an important role in plants have been discovered in recent years. In many cases, these metabolites are unique to the individual species. In order to obtain these active compounds for sample preparation, qualitative and quantitative analysis, the initial step in separating active compounds from plant materials can be referred to extraction. There are number of conventional extraction methods for separation purpose. Some methods have been used for many years such as soxhelt extraction (SE), heat reflux extraction (HRE), steam distillation (SD) and solvent extraction. Now-a-days, many novel techniques for extraction of active compounds including Ultrasound assisted extraction (UAE), Microwave-assisted extraction (MAE), Supercritical fluid extraction (SFE).

Biography:

Dr Ashutosh Chaturvedi has completed his graduation from Rajiv Gandhi University of health sciences, Bangalore, specialized in Panchakarma (Ayurveda Bio-purification) and received Post experience certificate in Diabetes Care from Glasgow, UK. He has standardised various experimental models for proving evidence for the use of the Bio purification methods over Diabetes. He is currently working as resident in Department of Panchakarma at SDM College of Ayurveda and Hospital, Hassan, India. He has published more than 26 articles in reputed journals, written book on “Ayurvedic Bio purification a remedy for Syndrome X” and received many best scientific paper in various international Conferences.

Abstract:

Panchakarma (Bio purification methods) is one among the main mode of treating the disorders in Ayurveda (alternative medicine). These are specially designed procedures of internal purification of the body through the nearest possible route. Such purification allows the biological system to return to homeostasis, rejuvenate rapidly and also facilitate the desired pharmaco-therapeutic effects of medicine. Such purification methods not only provides the biochemical changes whereas it further prevents the disease progress. IDF guidelines states that Type 2 Diabetes demands multi professional approach which should include the usage oral medication, dietary intervention, weight loss mechanism and exercise. In all such presentation all these benefits are gained by these methods as they are target specific and provides quicker relief in comparison to conservative medicine. Experimental study over these therapy revealed its target specific evidence for the clinical studies. Only single intervention helps to initiate the weight loss mechanism in the body with decrease in the central obesity, Fasting blood glucose, Serum triglyceride, Waist circumference, Hip Circumference, Waist hip ratio and Body weight whereas in experimental study it shows decrease in the Fasting Blood glucose, serum triglyceride and reduced fatty changes in liver, heart and kidney. This decrease in fatty acid in the storage like liver, kidney, heart and muscle adipose tissue can indirectly increase the insulin sensitivity in insulin receptor present at skeletal muscles. Therefore from its holistic approach bio purification of Ayurveda scientifically can be line of management for Type 2 Diabetes.

Biography:

Dr. Rohit A received MD in Community Medicine from the prestigious RGUHS, Bangalore. He is working as Assistant Professor in the Medical College and also the assistant training co-ordinator for Non Communicable Disease training for Government health professionals conducted by KHSDRP with World Bank aid.

Abstract:

Objective: To assess 10 year risk of a fatal or non-fatal cardiovascular event in adults attending diabetes screening clinic using WHO/ISH risk prediction chart. Methodology: A Cross sectional, pilot study was carried out among adults attending non communicable disease [diabetes] screening clinics in Davanagere district over a period of two months. One clinic was selected from urban and two were from rural locality. 181 adult subjects took part in the study. WHO/ISH Risk predictions charts were used to predict 10 year risk of a fatal or non-fatal cardiovascular event among the adults. Data entered using Epidata3.1, analysed using IBMSPSS20.0. Results: Among the 181 subjects, 70.2% [127] were from urban and 29.8% [54] were from rural background. 70.2%[127] subjects had < 10% risk and 3.3% [6] had >40% risk of cardiovascular event in the next 10 years .Among the 37 diabetic subjects, 70.3 %[26] were from urban and 29.7%[11] were from rural background. There was significant difference between urban and rural subjects [p<0.05] in relation to tobacco consumption and hypertension. No significant difference was observed between urban and rural subjects [p>0.05] in relation to diabetes and cardiovascular risk occurrence. There was significant difference between random blood sugar level among diabetic and non-diabetic subjects in rural area [p<0.05]. Conclusion: Cardiovascular risk counselling should be integral part of non-communicable disease screening and management programmes. Effective control of blood sugar level in diabetic patients needs improvised strategies in community setting. Cardiovascular risk factors like tobacco consumption, hypertension which has compounding effect needs to be addressed at individual level of counselling

Biography:

Moorkath Nandakumaran obtained his Doctorate degree (PhD) in Reproductive Physiology from University of Paris VI, France in 1979. He worked for 4 years as Research Consultant in Biochemical Pharmacology at St. Vincent de Paul Hospital, Paris, France. He is currently working as Professor of Obstetrics and Gynecology at Kuwait.

Abstract:

iabetes Mellitus in pregnancy is well known to be associated with increased maternal as well as neonatal mortality and morbidity. Altered disposition of essential trace elements and anti-oxidant function have been implicated in genesis of the disease as well as in increasing incidence of congenital mal-formations in the diabetic state as well. Previous studies in our laboratory have shown altered maternal-fetal disposition of some essential trace elements such Cu, Fe, Mo, Se and Zn in both insulin-dependent as well as gestational diabetic pregnancies. However there have been no reports to date on maternal-fetal transport of essential trace elements such as Cr, Mn and V in diabetic pregnancies in humans or experimental animals. Here we report for the first time in the literature maternal-fetal transport kinetics of the above mentioned trace elements in control and normoglycemic state and have explored the possible effect hyperglycemic diabetic state on the transport kinetics of the above elements in diabetic model human placental lobule in vitro, using perfusion of isolated human placental lobules in vitro. This perfusion method has been used extensively by us in assessing maternal-fetal transport of a variety of drugs and nutrients, including essential trace elements in control as well as diabetic pregnancies as well. Our studies show that hyperglycemia state alters maternal-fetal transport kinetics of above trace elements in vitro which could have nefarious fetal effects on the baby in the womb in hyperglycemic diabetes states.

Biography:

Abstract:

We are facing challenge of increasing elderly population with diabetes and prediabetes.
The problems that are specific to elderly diabetics include : (i) Non responsive bacterial and fungal infections, (ii) Hypoglycemia, (iii) Frequent falls, fatigue, dizziness, (iv) Increased Incontinence and bladder dysfunction, (v) Electrolyte imbalance and Nutritional deficiencies, (vi) Hyperosmolar Non-Ketotic Coma, (vii) Frozen Shoulder, (viii) Cardiovascular events,(ix) Renal decompensation, (x) Hepatic Dysfunction, (xi) Depression, Anxiety, (xii) Neurological complications,etc to name a few. All these factors exert serious impact on quality of life of the patient as well as aggravated healthcare burden and cost.
The goal of treatment differs in elderly. A delicate balance between Hypoglycemia and Hyperglycemia has to be maintained. Medical Nutrition therapy and Exercise therapy have to be Individualised keeping in view the functional and physical capacity of the person as well as their socio-economic status. Home monitoring of Blood Glucose and Blood Pressure should be advocated as frequent hospital visits may not be possible for elderly people. Optimal use of modern technology for communication should be utilised for monitoring the patient. Drug therapy should be designed considering the co morbidities, side effects of drugs and drug-drug interaction between various drugs. Drugs with multiple effects and combination therapies can be advocated to reduce the pill burden.
Thus, though care of elderly diabetic is a challenging task, it can be efficiently handled with team effort of qualified physician, diabetes educator, nutritionist, supportive family member, attendant and patient. Individualisation of therapy is key to good management of an elderly diabetic.

Biography:

Purbajit Chetia has completed his MPharm in 2012 from Sikkim University and enrolled PhD in Assam Down Town University, Guwahati, Assam. Currently, he is working as an Assistant Professor in the Department of Pharmaceutical Science in Assam Down Town University. He is having a few research publications in reputed journals.

Abstract:

Diabetes mellitus is a metabolic disorder characterized by hyperglycemia that results from defects in insulin secretion and action or both. The presence of DM employs increased risk of many complications such as cardio vascular disease, coronary artery disease, stroke, neuropathy, renal failure, renal failure, retinopathy etc. This study concentrates on the experimental investigation of the anti-diabetic activity of the leaves of Plantago major Linn (Family: Plantaginaceae). Diabetes was induced in Wister rats used for this study by streptozotocin. The methanolic extracts of leaves of Plantago major were administered orally (100 and 200 mg/kg, for 15 days). Hypoglycemic effects, oral glucose tolerance test, change in body weight and lipid profile of diabetic rat treated with methanolic extracts were determined and compared with normal, diabetic control and standard drug treated rats. Histological examination during 15 days of treatment was also carried out. Methanolic extract (200 mg/kg) produced a significant reduction in fasting blood glucose level in streptozotocin-induced diabetic rats. Significant differences were also observed in urine glucose level, oral glucose tolerance test, serum lipid profile and body weight of methanolic extract treated diabetic rats, when compared with diabetic, normal and standard drug treated rats.

Biography:

Koushik Nandan Dutta has completed his MPharm in 2013 from Uttarakhand Technical University, Dehradun and enrolled PhD in Assam Down Town University, Guwahati, Assam. He has completed 1 year project at Defense Research laboratory, Tezpur Assam. Currently he is working as an Assistant Professor in the Department of Pharmaceutical Science in Assam Down Town University. He has published eight publications in reputed journals.

Abstract:

Diabetes mellitus (DM) is a chronic disease caused by inherited or acquired deficiency in production of insulin by the pancreas, or by the ineffectiveness of the insulin produced. India has today become the diabetic capital worldwide over 20million diabetes and this number is set to increase to 57 million by 2025. Decreased physical activity, increasing obesity, stress and changes in food consumption is the main reason for causing Diabetes mellitus. Though different types of oral hypoglycemic agents are available along with insulin for the treatment of diabetes, there is an increase demand by patients to use natural products with anti-diabetic activity. The present study was carried out to investigate the anti-diabetic potential of ethanolic extract of the leaves of Sonchus asper (Family- Asteraceae) and Sonchus arvensis (Family-Asteraceae). Oral administration of ethanol extract in the doses of 100, 150 & 200 mg/kg body weight to white Wistar rats significantly reduced their blood sugar level in alloxon induced diabetic rats under acute and sub-acute studies. The results showed that the ethanol extract doses of 200mg/kg b-wt have significant anti-hyperglycemic effect in experimental model of diabetes mellitus. Based on the results, it can be reasonably concluded that both Sonchus species has antidiabetic activity. This study also becomes a valuable reference for further research.

Biography:

Maria Letizia Iabichella is a medical doctor graduated at the University of Pisa (Italy) and specialized in angiology. She is interested in clinical and home wound care management and in microvascular research by non invasive diagnostic methods. She is currently a lecturer at the University of Siena (Italy) and author of several articles. She has developed a new method to treat vascular, diabetic and Buruli ulcer with ozone. She founded Helios Med Onlus, International Health Cooperation, in 2011 aimed at training staff to perform social and health activities and sharing wound care know how through missions abroad.

Abstract:

The efficacy of the treatment with Hyperoil (mixture of Hypericum perforatum flowers extract and Azadirachta indica oil) in advanced ulcerated diabetic, vascular and neuropatic feet was described in a previous reports. Several surprisingly successful outcomes for infection damaged diabetic foot, without prior use of surgical procedure, demonstrated the great potential of the Hyperoil. In fact, the effective use of treatment with Hyperoil in patients with foot diabetic lesions was proved in a case series study.
Current research lines in regenerative medicine focus on the creation of scaffolds with specific functionalities and structurally similar to the fibrous component of the Extra-Cellular Matrix, thus providing a biomimetic environment for cellular growth. The use of electrospun scaffolds made by Poli(L-lactic acid, PLLA) functionalized with Hyperoil, having anti-infective properties, was recently demonstrated by using S. aureus, P. aeruginosa and K. ozaenae AM strains. In our preliminary observations, the scaffold functionalized with Hyperoil was applied directly in cleaned skin ulcers after debridment, showing also anti-inflammatory and tissue regeneration properties without perilesional damage. In particular, the biomimetic structure of the PLLA mat remarkably improves the tissue repair efficacy of Hyperoil used as regenerative skin graft easing wound healing time, avoiding surgical procedures in operating room and high costs for hospedalization.
The outcome of the cooperation between regenerative medicine and tissue engineering fields lead to the development of scaffolds functionalized with Hyperoil which might be used use in extensive skin tissue loss like Buruli ulcer and burns due to their bacteriostatic, anti-flammatory and regenerative properties.

Biography:

R Dhananjayan has completed his Post-graduation in Medical Biochemistry (Faculty of Medicine) from PES Institute of Medical Sciences & Research, Andhra Pradesh and PhD in Medical Biochemistry (Faculty of Medicine) from Nizam’s Institute of Medical Sciences (NIMS), Hyderabad, Telangana. He has been awarded the Young Scientist Award-2008 and has won fellowship awards from Association of Clinical Biochemists of India. He has attended many national/international conferences and published many scientific papers in national/international journals. He is serving as a Faculty for MBBS, BDS, MDS and other health science courses for more than 14 years.

Abstract:

Functional polymorphism in genes regulating one-carbon metabolism and deficiency of micronutrients such as folate, vit-B12, vit-B6 etc., perturbate one-carbon metabolism. Hence they are associated with elevated plasma homocysteine (HCY) and decreased functional folate, S-adenosyl methionine (SAM) and glutathione (GSH). Elevated HCY acts as pro-oxidant and found to generate free radicals by auto-oxidation, inducing lipid per-oxidation, causes endothelial cell damage and also perturbing hemostasis. Decreased levels of folate are associated with defective synthesis of purines and uracil mis-incorporation in DNA. Decreased SAM with increased S-adenosyl homocysteine (SAH) blocks methyl transferases, leading to decreased cellular methylation and is associated with altered gene expression. The above events are likely to lead atherosclerosis and arterial thrombosis. Several SNPs were reported in genes regulating the one-carbon metabolic pathway interfere with the uptake of folate, folate carrier, DNA synthesis, synthesis of methyl tetra-hydrofolate, remethylation of HCY and reductive methylation of cobalamin. Among different polymorphisms of one-carbon metabolism, i.e., glutamate carboxypeptidase II (GCPII C1561T), reduced folate carrier 1 (RFC G80A), serine hydroxyl methyl transferase 1 (cSHMT C1420T), thymidylate synthase (TYMS 5’UTR) 28bp tandem repeat, methylene tetrahydro-folate reductase (MTHFR C677T) and 5-methyltetrahydrofolate homocysteine S-methyl transferase (MTR A2756G), the extensively studied polymorphisms in CAD are GCPII C1561T, MTHFR C677T and MTR A2756G. MTHFR C677T has been observed to be associated with independent risk for CAD in the subjects with low folate status. The increased oxidative stress is one of the main factors in etiology and complications of diabetes mellitus (DM). GSH is the major cellular antioxidant, detoxifies ROS, reduces peroxides and detoxifies multiple compounds through glutathione-S-transferase (GST) conjunction. GSTs defend cells against a wide variety of toxic insults from chemicals, metabolites and oxidative stress. An important condition affecting GST expression is oxidative stress, usually observed in DM. Folate and its metabolites play an important role in the synthesis, repair and methylation of DNA and hence any aberration in this metabolic pathway may lead to hyper homocysteinemia which might contribute to etiology of CAD. Xenobiotic metabolism is the principle pathway that scavenges lipophilic xenobiotic agents and certain endogenous metabolites. Any alteration in this metabolic pathway prevents scavenging and increase reactive intermediates that have the potential of oxidative damage.

Biography:

Abstract:

Biography:

Dr. Ravinder Singh is currently the Director of the Endocrinology Laboratory at the Mayo Clinic. One of his areas of expertise is application of liquid chromatography tandem mass spectrometric (LC-MS/MS) to clinical laboratory analysis. Many of the methods which he has developed are now considered reference methods, and have subsequently been utilized for method standardization efforts. As a result, the clinical diagnosis of Diabetes, Cushing’s disease, pheochromocytoma and congenital adrenal hyperplasia have been improved. He has published his work on originally developed methods including such analytes as cortisol, synthetic corticosteroids, metanephrines, estradiol, vitamin D, and urine albumin amongst others. Dr. Singh is also the Co-PI of 3 grants. He is Co-director of the ICL lab which supports the Human research protocols. He was recently granted a Novel methodology CTSA award for “Development of Robust LC-MS/MS Based Methods for the Absolute Quantification of Proteins and Peptides.” And he was recently awarded AACC Outstanding Speaker Award, as well as MSACL Leadership Award for Mass Spectometry Applications to the clinical lab.

Abstract:

The quality and standardization of HbA1c methods in the clinical laboratories will be discussed. The differences in various methods for mesuring HbA1c will be highlighted. The gold standard methodolgy and challenges in standardization of the testing will be presented. Interferences and specificty related to various Insulin assays will also be discussed. The quality of the POCT for glucose in real life will also be highlighted. How use of artificial pancreas will impact the management of diabetes will be part of the discussion as well.

Biography:

Dr Ashutosh Chaturvedi has completed his graduation from Rajiv Gandhi University of health sciences, Bangalore, specialized in Panchakarma (Ayurveda Bio-purification) and received Post experience certificate in Diabetes Care from Glasgow, UK. He has standardised various experimental models for proving evidence for the use of the Bio purification methods over Diabetes. He is currently working as resident in Department of Panchakarma at SDM College of Ayurveda and Hospital, Hassan, India. He has published more than 26 articles in reputed journals, written book on “Ayurvedic Bio purification a remedy for Syndrome X” and received many best scientific paper in various international Conferences.

Abstract:

Panchakarma (Bio purification methods) is one among the main mode of treating the disorders in Ayurveda (alternative medicine). These are specially designed procedures of internal purification of the body through the nearest possible route. Such purification allows the biological system to return to homeostasis, rejuvenate rapidly and also facilitate the desired pharmaco-therapeutic effects of medicine. Such purification methods not only provides the biochemical changes whereas it further prevents the disease progress. IDF guidelines states that Type 2 Diabetes demands multi professional approach which should include the usage oral medication, dietary intervention, weight loss mechanism and exercise. In all such presentation all these benefits are gained by these methods as they are target specific and provides quicker relief in comparison to conservative medicine. Experimental study over these therapy revealed its target specific evidence for the clinical studies. Only single intervention helps to initiate the weight loss mechanism in the body with decrease in the central obesity, Fasting blood glucose, Serum triglyceride, Waist circumference, Hip Circumference, Waist hip ratio and Body weight whereas in experimental study it shows decrease in the Fasting Blood glucose, serum triglyceride and reduced fatty changes in liver, heart and kidney. This decrease in fatty acid in the storage like liver, kidney, heart and muscle adipose tissue can indirectly increase the insulin sensitivity in insulin receptor present at skeletal muscles. Therefore from its holistic approach bio purification of Ayurveda scientifically can be line of management for Type 2 Diabetes.

Biography:

Rohit A received MD in Community Medicine from the prestigious RGUHS, Bangalore, India. He is working as an Assistant Professor at Medical College and also as an Assistant Training Co-Ordinator for Non Communicable Disease training programme for Government health professionals conducted by KHSDRP with World Bank aid. He is involved in the review of manual on NCD [Diabetes, Hypertension and Cancer cervix] for KHSDRP, Government of Karnataka. He is a resource person for NACO CME series in 7 Medical colleges of Karnataka and certified Master Trainer for Emergency Care and Life support [ECLS] by Utah University, Salt Lake City, USA and RGUHS, Bangalore. He is credited with 7 presentations at various international, national and state conferences.

Abstract:

Objective: To assess 10 year risk of a fatal or non-fatal cardiovascular event in adults attending diabetes screening clinic using WHO/ ISH risk prediction chart. Methodology: A Cross sectional, pilot study was carried among adults attending non communicable disease [diabetes] screening clinics in Davanagere district, India over a period of two months. One clinic was selected from urban and two were from rural locality. 181 adult subjects took part in the study. WHO/ISH risk prediction charts were used to predict 10 year risk of a fatal or non-fatal cardiovascular event among the adults. Data was entered using Epidata3.1 and analysed using IBMSPSS20.0. Results: Among the 181 subjects, 70.2% [127] were from urban and 29.8% [54] were from rural background. 70.2% [127] subjects had <10% risk and 3.3% [6] had >40% risk of cardiovascular event in the next 10 years. Among the 37 diabetic subjects, 70.3% [26] were from urban and 29.7% [11] were from rural background. There was significant difference between urban and rural subjects [p<0.05] in relation to tobacco consumption and hypertension. No significant difference was observed between urban and rural subjects [p>0.05] in relation to diabetes and cardiovascular risk occurrence. There was significant difference between random blood sugar level among diabetic and non-diabetic subjects in rural area [p<0.05]. Conclusion: Cardiovascular risk counselling should be an integral part of non-communicable disease screening and management programmes. Effective control of blood sugar level in diabetic patients needs improvised strategies in community setting. Cardiovascular risk factors like tobacco consumption and hypertension which has compounding effect needs to be addressed at individual level of counselling.