Biography:

Arun Gowda is a Director of Focus Scientific Research Center(FSRC)A physician by training, Arun has worked in various fields of the health sector ranging from clinical practice, business and clinical research, brand positioning, behavioural change and digital marketing.

Abstract:

Recent International Diabetes Federation (IDF) update depicts that globally there are 387 million people with diabetes and 77% of this population belongs to low and middle-income countries. This number is predicted to increase in the next 20 years to 592 million which also include diabetes in pregnancy (DIP). Especially, women with Gestational Diabetes Mellitus (GDM) and their children are at increased risk of future diabetes. In India, GDM prevalence has steadily increased from 2% (1982) to 7.62% (1991) and doubled to 16.55% in 2002. However, based on the geographical locations and diagnostic methods used the prevalence ranged from 3.8 to 21%.There was a research gap identified to understand this burden in the country. Hence, an analysis was performed on existing country-specific DIP research in India and compared to the research done in the United States of America (USA). The IDF’s 2000-2035 estimates show that the diabetes prevalence in India has and will increase steadily: in comparison, the USA has shown a decrease in 2011. Through an elaborate search on PubMed it was found that a total of 129 articles had been published on DIP from 1947 to 2014 in India, less than a tenth of the 2412 articles published from 1972 to 2014 in USA. Therefore, this analysis indicates a clear need for greater study on Indian specifics. Although, worldwide there are many ongoing studies to address the growing burden of diabetes in terms of health, economy and social well-being, there is a need for further research in India. It was concluded that despite the increasing diabetes prevalence in India there are insufficient research to know the actual facts and figures to gauge the disease impact. Focus in this area towards further research would contribute valuable information for better management of DIP in India and to facilitate rational allocation of limited resources, thereby improving healthcare access

Biography:

Mohammed Suhail Hussain M has obtained his MSc in Biotechnology from University of Madras in 1998 and completed his MPhil in Advanced Biochemistry in 2012 from Thiruvalluvar University. He worked as Assistant Prof. in the Department of Environmental Engineering at K A R Polytechnic College, Ambur. Later he joined as Product Promoter and after few years became Manager in Immuno division, CPC Diagnostic Company. Presently he is pursuing his Doctorate degree under the guidance of Dr. Mazher Sultana at Marine Biotechnology, AMET University, Chennai.

Abstract:

Diabetes is a serious disorder which leads to various micro and macro vascular complications. The main purpose of the study is to find out the most common complications and the difference of WBC among the workers of match and fire workers of Sivakasi area Tamil Nadu, India. For this study 173 (99 male and 74 female) diabetic workers having diabetic complications were selected and their behavioral and socio-economic data were collected by individually asked questions and clinical analysis done on their blood samples. Cardiovascular (29%) and Neuropathy (28%) were present high among the workers. Total count was more in cardio vascular workers. At the same time neutrophil count was high and lymphocyte count was low in cardiovascular complications compared to other complications.

Biography:

Post graduate in kmc mangalore, final year

Abstract:

The prevalence of hyperuricemia has been increasing in recent years, not only in advanced countries but also in developing countries, along with development of their economy. The metabolic syndrome is a growing public health problem in the world. Components of the metabolic syndrome including Diabetes, Hypertension, Dyslipidaemia. A total of 60 people with metabolic syndrome were included. Metabolic syndrome was defined as per ATP III guidelines. Hyperuricemia was defined with cutoff >6.8mg/dl in both men and women. Associated work up for metabolic syndrome and insulin resistance like FBS,FLP,FASTING INSULIN,SERUM URIC ACID was done. Blood pressure and anthropometric measurements including weight, height & waist circumferences were measured and BMI calculated. HOMA IR method was used for calculating insulin resistance. Logistic regression analysis was used to evaluate association of hyperuricemia with metabolic syndrome and insulin resistance.

Biography:

Mr. Plaban Bhattacharya did his M. Pharm. from Jadavpur University, pursued Ph.D. research work as Senior Research Fellow of CSIR, New Delhi and presently writing his PhD Thesis. His supervisor Prof. Achintya Saha, in the Department of Chemical Technology, University of Calcutta is working in analytical method development including metabonomics and toxicity studies. He has published more than 70 papers in reputed journals.

Abstract:

Severe maternal, foetal and neonatal doldrums are coupled with gestational diabetes mellitus (GDM). Search, validation and implementation of new and safe medications are necessary. Triphala is an ancient herbal formulation effective in several disease conditions. However its effect in GDM is reported to be ambiguous. In the present investigation, the hydro-ethanolic extract of prepared triphala powder was complexed with 2-hydroxypropyl-β-cyclodextrin (BCD), for mainly unpleasant taste masking, bioavailability and stability enhancement. The TR-BCD complex in different dose levels were administered in pregnant, streptozotocin induced diabetic rats. Serum metabolite and antioxidant status, pregnancy outcomes and neonatal malformations were found to be beneficial in comparison to diabetes-control. Liver and kidney histology showed major recovery. Estrus cycle duration and concentration of serum gonadotropin and gonadal hormones were found to be normal in TR-BCD treated group (25 mg/kg/day, administered from day 1 to 16 of pregnancy). The inclusion complex of TR-BCD was characterized by TEM, DLS and HPTLC analyses. TR-BCD nanospheres were found to be a sustained release delivery device and should be explored further to unravel its mechanism of action.

Biography:

Naini Bhadri is pursuing her PhD in Pharmacology from Rajiv Gandhi University of Health Sciences Bangalore (Karnataka). She is a Senior Research Fellow of Indian Council of Medical Research, New Delhi. She has presented research posters in many National and International conferences.

Abstract:

The study was conducted to investigate the neuroprotective potential of allantoin against biochemical, behavioural and electrophysiological deficit in streptozotocin (STZ) induced peripheral neuropathy in diabetic rat. Oral administration of allantoin (100 & 200 mg/kg; per oral) began on the confirmation of diabetes after 72 hours of STZ treatment and was continued for 8 weeks in Wistar albino rats. Determination of body weight and behavioural tests were performed subsequently in every two week during allantoin treatment period. In addition sciatic nerve conduction velocity studies and biochemical parameters of nerve homogenate and serum were performed. In vitro antioxidant activity and AGE (advanced glycation end product) inhibitory assay of allantoin were also performed. Animals treated with allantoin showed a significant improvement in body weight and reduction in serum blood glucose levels as compared to vehicle-treated diabetic rats. Moreover, significant improvement was noted in hyperalgesia, grip strength muscle co-ordination and nerve conduction velocity in allantoin treated diabetic rats. In sciatic nerve there was a significant increase in MDA level and poor antioxidant levels were observed. Reduction in MDA level and NO was determined nevertheless increase in the antioxidant level was perceived in allantoin treated group. Allantoin treatment shows efficacy for preventing diabetic deterioration as seen by improvement in biochemical, behavioural and electrophysiological deficit. The neuroprotective effect of allantoin could be attributed to its anti-hyperglycemic, AGE inhibitory activity and reduction in oxidative and nitrosative stress.

Biography:

Nivedita E is currently pursuing Post-graduation in General Medicine from Mahatma Gandhi Medical College and Research Institute, Pondicherry, India. She has done an oral presentation at The Association of Physician’s of India-Tamil Nadu chapter and also participated as a delegate in CMEs conducted by various organisations such as Pondicherry Association of Neuroscientists and Indian Medical Association in 2014 at Pondicherry, Association of Surgeons of India in 2013 and 2015 at Pondicherry, Urgencies Chirurgicales in 2013 at Pondicherry, programme on advances in critical care and emergency, 5th national annual conference in 2013 at Pondicherry. She is also a member of the American Heart Association accredited basic life support and advance cardiac life support course since 2013.

Abstract:

We describe a case of a 55-year-old male with a 10 -year history of type 2 diabetes mellitus, who was presented to our casualty with complaints of sudden onset of left thigh pain and swelling. On evaluation, his blood sugars were found to be elevated, his glycosylated haemoglobin value was high, ESR was raised, CK value was 1800 U/L. We made a presumptive diagnosis of pyomyositis and initiated intravenous antibiotics, but he showed no improvement. Blood and tissue samples were examined for microorganisms and demonstrated no white blood cells and no organisms. Then an MRI of the limb was considered for further evaluation.

Biography:

Richa Chaturvedi has submitted her PhD at the age of 29 years from Assam University and completed her JRF (2010-2012) as well as SRF (2013-2015) from DRDO, Tezpur, India. She has published two international papers and communicated two more. She has attended three national conferences and is a reviewer of many reputed Journals.

Abstract:

High concentrations of iron in the body can inhibit phagocytosis and transporter proteins. If there is a reduction in the liver iron, it can improve the glucose/insulin axis. This study documents the effect of administration of iron rich water on hemolytic anemia in a Wistar rat’s animal model. Hemolytic anemia was induced intraperitoneally by phenyl hydrazine and diagnosed by blood hemoglobin lowering. After inducing the hemolytic anemia, 24 Wistar rats (n=6 in four groups) were randomly assigned to 1mg/l, 5 mg/l and 10 mg/l ferric oxide iron along with 1mg/l ascorbic acid administered through drinking water, a control group was treated with iron-free water. After 30 days of treatment, the hematological and biochemical parameters, iron levels in liver, spleen and kidney were estimated. A significant increase of serum iron and ferritin and a decrease of TIBC (total iron binding capacity) were observed without changes in other biochemical parameters in the group treated with 5mg/l iron and ascorbic acid. However, in the group treated with 10 mg/ml iron and ascorbic acid, hematological changes with significantly higher values for white blood cell count, glucose, splenic and liver iron content indicates potential toxicity at this supplementation level. The result suggest that the optimum concentration of iron (5 mg/l) and ascorbic acid may improve anemic conditions and may be therapeutically beneficial in the treatment of anemia without any negative impact, while 10 mg/l in drinking water seems to be the threshold for the initiation of toxicity.

Biography:

I Mary Priyanka Udumula completed Bachelors of Pharmacy from kakatiya university securing 10th rank, Masters in Pharmacology from kakatiya universiity securing university 1st rank. Joined as DST inspire junior research fellow with inspire fellowship in Birla institute of Technology-PILANI, Hyderabad campus.

Abstract:

Double-stranded RNA-dependent protein kinase (PKR) is a serine/threonine protein kinase activated by various stress signals and plays an important role in obesity, insulin sensitivity and glucose homeostasis. Indirubin-3'-oxime (I3O) is an effective inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3-beta (GSK-3). However, the effects of I3O on PKR expression and related consequences in cultured rat cardiomyocytes have not been reported. The aim of the present study was to investigate whether I3O attenuates the effects of high glucose on PKR, oxidative stress and apoptosis in cultured rat cardiac myocytes. Q- PCR, western blotting, DAPI staining and DCFDA assay were done to measure protein/mRNA expression, apoptosis and reactive oxygen species levels respectively. High glucose treatment caused significant increase in PKR mRNA expression which was attenuated by co-treatment with Indirubin-3-oxime. High glucose treated cultured cardiomyocytes developed a significant increase in mRNA expression for JNK, caspase-3 and NF-KB, which were all attenuated by pretreatment with I3O. There was also a significant increase in reactive oxygen species generation as well as apoptosis in high glucose treated cultured cardiomyocytes, which was attenuated by pretreatment with Indirubin-3-oxime. In conclusion, I3O may have a preventive role against the deleterious effects of high glucose in the heart.

Biography:

Vinay kumar Is currently working at Pathshodh healthcare Private Limited,India.He is also interested in doing research in field of Diabetes. Centre for NanoScience and Engineering (CeNSE) Indian Institute of Science.

Abstract:

Diabetes is rapidly emerging as a major threat to public health. Diabetes is not a single disorder, but is a collection of several disorders with different underlying causes and with multiple hormonal abnormalities. It is characterized by disordered carbohydrate metabolism with hyperglycemia resulting from dysfunction of insulin secretion, insulin action or both. The long term complications of diabetes mellitus include the progressive development of retinopathy, nephropathy, foot ulcers, neuropathy, cardiovascular diseases and amputation. Albumin is one of the most abundant protein in plasma. The normal concentration of the albumin in plasma is 35 to 50 g/l. Albumin protein has three domains I, II, III that are further subdivided into two subdomains, A and B which enable its functional conformational structure. Presence of 17 disulphide bridges make it resistant to the change in the pH and other altering environment. Hyperglycemia in diabetes mellitus induces the formation of the advanced glycation end products (AGE), thought to be toxins that bind to proteins present in plasma. HbA1c, which gives 90 days average blood glucose level, is clinically recommended as gold standard for assessment of the glycemic control in diabetic patients. Glycated albumin (GA) has been recently used as another clinical gold standard indicator of glycemic control. Since the half life of human serum albumin is 2 weeks, it could serve as an efficient marker for short term glycemic control compared to HbA1c. Further HbA1c test results could be affected in a number of situations, such as structural hemoglobinopathies, thalassemia syndromes and chemical alterations of haemoglobin. Moreover, any condition that decreases mean erythrocyte age, such as chronic kidney disease, will falsely lower HbA1c test results regardless of the assay methods for assessments. We present a novel technology for electrochemical detection of serum albumin that is being extended for glycated albumin measurement for point of care application by exploring the binding property of albumin with electrochemically active molecules such as copper and hemin. Fig. 1 shows the linearity redox current as a function of Albumin concentration. Fig. 2 presents the handheld device capable of

Biography:

Mr. Abhishek Bharadwaj is working as an Assistant Professor at Teerthankar Mahaveer College of pharmacy, Teerthankar Mahaveer University, Moradabad, U.P. INDIA. He has completed his D. Pharm., B.Pharm and M.Pharm from Rajiv Gandhi University of Health Sciences, Karnataka. He has more than eighteen publications in various National and International research journals. He has Editor-In- Chief of Indian Journal of Pharmaceutical and Biological Research and he is having about 8 Year Teaching experience and he is associated with various association and he has completed is PhD from Uttrakhand Technical University, Dehradun U.K.

Abstract:

The aim of the research work is polyphyto combination compression of different antilithiogenic agent and to screen its toxicity by Caco-2-cell line. Polyphyto combination was prepared by geometrical dilution method; it was subjected for aqueous and alcoholic extract. The formulation and extract were screened for its initial in vitro toxicity study using Caco-2-cell line by 3-(4, 5 dimethyl thiazole-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) assay method for aqueous extract of formulation. It showed nontoxic to Caco-2-cell line, even at high dose, that is, 1000 µg/ml, whereas aqueous extract (FH1) exhibited moderate toxicity CTC 50 value 875±35.3 µg, FH1 crude formulation showed significant toxicity against Caco-2-cells with low concentration with CTC 50 value 382.75 based on this result the conclusion was drown that the formulation FH2 and aqueous extract of FH1 is devoid of toxicity. The cells were dissociated with TPVG solution (0.2% trypsin, 0.02% EDTA, 0.05% glucose in PBS).

Biography:

Myself Dr.Parth S Prajapati has completed my MBBS from Govt Medical college Bhavnagar Gujarat and at present working as 3rd year resident MD(Medicine) from the same college.

Abstract:

Acute coronary syndrome is one of the leading cause of all cause mortality as far as cardiac cause of death is concerned.Serum Homocysteine has emerged as one of the independent risk factor for acute coronary syndrome.It causes damage to the endothelium of the arteries and leads to thrombosis . Elevated homocysteine cause endothelial cell injury which induces oxidative stress to the endothelium and reduces nitric oxide, it may also generate free radicals and inhibit production of other antioxidants. Endothelial injury is followed by platelet aggregation and thrombus formation.Here my study strongly proves that elevated homocysteine level is really a risk factor for acute coronary syndrome.

Biography:

Presently, I am pursuing Final MBBS Part-1 from Deccan College of Medical Sciences at Hyderabad, India. I carried out this research in 2014 as an ICMR-STS based study under the guidance of my professor.

Abstract:

According to Diabetes atlas 2009 India has 51 million people with diabetes. However, there has been no nationwide survey of Diabetes in India except for ICMR-INDIAB study which was initiated in phase manner (2009) Unfortunately more than 50% of the Diabetic subjects in India remain unaware of their Diabetic status, which adds to the disease burden. This underscores the need for mass awareness and screening programmes to identify and overcome the burden due to Diabetes in India.
The Government of India has already initiated a national Diabetes Control Programme. For such programmes to be successful, it is necessary to determine cost effective methods for identifying undiagnosed Diabetic subjects in our country. The objective of this study was to screen and identify individuals with Impaired Glucose Tolerance (IGT) and/or Impaired Fasting Glucose (IFG), and thus estimate the burden of Pre-diabetes in the selected region.
According to this study the prevalence of pre diabetes was found to be 3.5%. The present study must be multi-centric to get the exact results of Pre diabetes. More studies have to be done to evaluate the risk factors. For the same purpose, the period of study also has to be long (cohort study).

Biography:

Justin Rayappa A, He did UG and M.Phil Zoology at Presidency College and M.Sc Zoology from Loyola College, Chennai. At present pursuing Part time PhD under the guidance of Dr. Mazher Sultana, Rtd. Prof and Head, presidency College Chennai through AMET University, ECR Chennai. Working as PG Assistant at Dominic Savio Hr Sec School, Chennai.

Abstract:

The practice of placing a small tobacco or chewing tobacco in the oral cavity and leaving it in place for extended period of time appears to be finding its way onto middle school, high school and college campuses as socially acceptable habits. Numerous reports in the literature have, described oral changes that appears to be associated with the use of smokeless tobacco in the adults. Such information is not available in the teenagers/adolescents/ lower age groups residents of SS Puram and SVM Nagar located in the Otteri area of North Chennai, Tamilnadu. A survey (Questionnaire) was used to collect information about students’ smokeless tobacco use, students’ current knowledge and the impact of smokeless tobacco on health. It was observed that smokeless tobacco habit is prevalent in males than female. Most common age to start smokeless tobacco was found as 12 and MAWA, HANS and Gutkha was most commonly used chewing material in Otteri area, consumed for more than five times a day by individuals with habit. Use of smokeless tobacco was appeared to cause a greater variety and severity of habit and tissue changes among the users than individuals without the tobacco habit

Biography:

Swati Waghdhare has published more than 100articles.currently working at Max Super Speciality Hospital, India.

Abstract:

Incidence of Diabetes in India was 1.09% in the 1950s, increased to 9.7 % in 1990, and 11% by 2000. There is a cost of care associated with its management and long-term complications of the disease.
We have worked incessantly towards providing improved medical care to the patients through innovative projects. Our 24*7 Telemedicine Diabetes Care Programme, a Specialized Super help line for individualized solution of patients, is based on new software design which supports patient’s full medical records across the world. National and International patients (mostly from Afghanistan) with diabetes keep in touch with our team doctors and diabetes educators on phone, web or through video calls. Our program “[email protected] Care 24*7” aims to expand access to important and much needed diabetes management services to patients across the world. This program was conceptualised in August 2013 and then the software was designed for its implementation. Our first set of patients was recruited in first quarter of 2014. Currently, we have 50 patients whom we are managing on-line and on call. We provided regular reminder services to our patients for tests and blood sugar monitoring. National and international patients who could not regularly come to our hospital call our team doctors and diabetes educators and take advice on their treatment. This improved follow-up and care of patients.
“[email protected] Care 24*7”, an ingenious, practical and sustainable system for intensive diabetes management, helps patients to effectively achieve and maintain goals within established treatment guidelines, regardless of geographical barriers.

Biography:

Abstract:

Molecular chaperones play a role in folding of nascent polypeptides into their biologically active structures. Also known as heat shock proteins(HSP), they respond to a wide variety of stress protecting the cell and their organelles against many chronically and acutely stressful conditions. Activation of HSP results in stress tolerance and also protection against stress induced molecular damage. Obesity which is associated with diabetes is linked to a state of chronic inflammation. Therein occurs release of various cytokines which lead to insulin resistance.
With an ever continuing rise of diabetes which is snowballing into an epidemic, chaperone proteins have been implicated in blocking inflammation and thus in the treatment of insulin resistance and obesity associated with type 2 diabetes mellitus.

Biography:

Diwesh Chawla has published articles in the field of his own research related to diabetes.He is interested in fields of immunology and biochemistry.his past works was carried out in Biochemistry and Immunology Laboratory, Department of Biochemistry, University College of Medical Sciences (University of Delhi)

Abstract:

BACKGROUND AND AIM: Advanced glycation end products (AGEs) are formed as a result of spontaneous non-enzymatic glycosylation of biomolecules, like proteins, lipids, nucleic acids. Interaction of AGEs with its receptor RAGE induces signal transduction that culminates in vascular complications, the major cause of morbidity and mortality in diabetic subjects. Some functional polymorphism of RAGE gene show differential activity of this receptor and therefore may be associated with the development of vascular complications in diabetic patients. In the present study we estimated blood level of AGEs and investigated the association of expression of RAGE gene and its genetic variants namely -374T/A and -429T/C in the promoter region and Gly82Ser polymorphism in the exon 3 region with vascular complications in T2DM patients.
METHODS: We screened 820 subjects which includes 200 healthy controls, 200 type 2 diabetes mellitus (T2DM) subjects without any vascular complications (DM), 220 T2DM subjects with microvascular complications (DM-Micro) and 200 T2DM subjects with macrovascular complications (DM-Macro) for -374 T/A, -429 T/C and Gly82Ser polymorphisms of RAGE gene. DNA isolated from the enrolled subjects were genotyped by PCR-RFLP. RAGE expression was determined by quantitative real-time PCR. Serum AGEs was estimated by spectrofluorometry
RESULTS: Serum AGEs level was significantly higher in diabetic patients having vascular complications as compared to T2DM without complications (p < 0.01). Mutant variant of -429T/C and Gly82Ser RAGE polymorphism was about three times more prone to develop macrovascular and microvascular complications respectively in T2DM subjects while -374A allele showed reduced risk towards the development of macrovascular complications (OR = 0.57, p = 0.006). Further, haplotype analysis revealed that CTG haplotype was significantly associated with the development of macrovascular complications while haplotype TAG was observed to be significantly protective towards development of macrovascular complications in T2DM subjects. The expression of RAGE correlated significantly with the genotypic variation of the RAGE gene.
CONCLUSION: Mutant genotypes of RAGE gene and enhanced formation and accumulation of AGEs under hyperglycemic conditions enhance RAGE expression in diabetic patients causing increased AGE-RAGE interaction, may be considered as risk factor for vascular complications in North Indian T2DM patients.

Biography:

Nimisha Jain working as Lecturer, Department Of Pharmaceutical Marketing and Management, Al-Ameen College of Pharmacy,india.She is currently working on Integration of Ayurveda and Pharmaceutical Technological Advances to make Effective Drug Delivery System of Gymnemic Acid.

Abstract:

Chronotherapeutic system are designed over the concept of chronopharmaceutics in which there is a specificity in delivering higher amount of drug in a burst at circadian timings correlated with specific pathological disorder to achieve maximum drug effect. In these systems there is a transient release of certain amount of drug within a short period of time immediately after a predetermined off-release period. Diabetes is one of the diseases where the constant drug levels are not preferred but needs a pulse of therapeutic concentration when the blood sugar levels are high. i.e., after the meals or at night (may be because of Somogyi Effect or Dawn Phenomenon). Circadian variations of glucose and insulin in diabetes have been extensively studied and the clinical importance of insulin substitution in diabetes has been well exploited. The chronotherapeutic system can be designed to achieve many pulsatile drug deliveries from a single system at the time when the blood sugar level is high i.e., after breakfast, after lunch and post dinner or late at night. The once a day drug Chronotherapeutic drug delivery system can be optimized to deliver the drug at the time of requirement of the body and at the site of its action and absorption in the gastro intestinal tract. The system also has the capability to incorporate single drug or multiple drugs with different mechanisms and site of action to achieve wholistic patient friendly treatment for the management of the disease.

Biography:

Dr. S.Jeyaparavathi has completed her PhD in Zoology, Manonmaniam Sundaranar University and post-doctoral research at MKU, Madurai. She joined LDC, Madurai as an Assistant Professor in 2013. She has published more than 26 papers in reputed journals.

Abstract:

Biomarkers for the early diagnosis of patients with acute and chronic pancreatitis (AP/CP) are needed to improve prognosis. To describe differences in microRNA expression in whole blood between patients with pancreatitis, acute and chronic pancreatitis with healthy participants and to identify panels of microRNAs for use in diagnosis of pancreatitis compared with acute and chronic compare with healthy controls. DESIGN, SETTING, AND PARTICIPANTS Differentially expressed miRNAs were validated in a larger cohort of patients and controls. The total RNA were collected from the patients’ blood serum and analyzed in 3 randomly determined different cohorts: discovery of large cohort (120 patients) with pancreatitis acute/ chronic pancreatitis compare with healthy controls. miRNAs were screened in the discovery cohort and novel microRNAs in the training cohort and other microRNAs in the validation. This study identified early diagnostic microRNA panels in blood serum samples that can be able to distinguish, to a certain grade of the AP.

Biography:

Lavanya Rayapu working as Assistant Professor at Department of Biotechnology, Dravidian University,India.

Abstract:

Sea weeds are a group of non-flowering marine plants commonly referred to as marine macroalgae. The edible sea weeds contain biologically active compounds with potential applications in functional food and nutraceuticals, hence they are used against several human diseases traditionally. The present study is to investigate the anti-diabetic and anti-oxidant activities of aqueous, ethanolic and methanolic extracts of different marine macroalgae in streptozotocin (STZ) induced diabetic rats. Oral administration of marine macroalgae extracts at a concentration of 125mg/kg body weight for 21 days treatment showed a significant decrease in fasting blood glucose levels and glycated hemoglobin (HbA1c) levels in marine macroalgae extracts coded AE3, FS4, FM4, OS1 and SS1 out of 30 extracts. Among these FS4 and FM4 showed more significant decrease in fasting blood glucose levels and glycated hemoglobin (HbA1c) levels. The results also demonstrated in significant increase in reduced glutathione, superoxide dismutase, catalase, glutathione peroxidase, glutathione-s-transferase and decrease in lipid peroxidase in liver, kidney and brain of diabetic rats. The results signify that sea weeds typically used as nutraceutical and functional food to reduce anti-diabetic and anti-oxidant effects in in vivo. Thus, the marine macroalgae extracts might have beneficial properties in the prevention of diabetes and could be useful in development of anti-diabetic pharmaceutical and functional food resources.

Biography:

Manche Santoshi Kumari is pursuing her PhD from Osmania University and is a research scholar of Institute of Genetics and Hospital for Genetic Diseases. She is currently working as scientist in MAA Research Foundation, Hyderabad, India

Abstract:

Diabetes mellitus is a systemic metabolic disease, characterized by fluctuating levels of glucose which affects multiple organs. Hearing loss is one of the most common otological disorders in adults with diabetes. This study aims to evaluate the prevalence of otological diseases and hearing loss patterns in adults suffering from diabetes. A total of 174 diabetic patients with hearing loss visiting MAA ENT Hospitals, Hyderabad, India constituted the study subjects. The patient’s age ranged from 40-80 years and the diagnosis was confirmed by otological examinations. Hearing loss was evaluated using pure tone audiometry and average for the frequencies at 0.5,1,2,4 and 8 kHz was recorded. Binary logistic regression analysis was used to determine the association risk factors with hearing loss in diabetes subjects. In the present study, otitis media (60.3%), presbycusis (27%) and otosclerosis (4.6%) were the common otological disorders in diabetic patients with hearing loss. 41.1 % of the total subjects were also affected with tinnitus. 44.3% of the subjects showed conductive, 38.5 % is sensorineural and 17.2 % is of mixed hearing loss. The prevalence of sensorineural hearing loss in tinnitus subjects is 34.3 % which was more compared to the patients without tinnitus. It was also observed that there was a significant association of sensorineural hearing loss (OR=4.23; 95% CI=2.10-8.49; p<0.001) with >60 years of age group. The present study revealed significant association of sensorineural hearing loss in elderly patients affected with co-morbid condition of diabetic mellitus.

Biography:

Dr.Allen Joe Rodrigues completed MBBS from AJ institute of medical sciences, Mangalore. Currently he is pursuing MD(Pharmacology) at Bangalore Medical College & Research Institute, Bangalore. This is one of the top 10 premiere medical colleges in India. His area of interest is in Diabetic Pharmacology.

Abstract:

In May 2009 FDA approved Bromocriptine QR , a central insulin sensitizer, as an antidiabetic drug either as monotherapy or as an add on therapy for type 2 diabetes. This systematic review is undertaken to assess the efficacy and safety of bromocriptine-QR in adults with type 2 diabetes mellitus based on randomized controlled trials published in peer-reviewed journals. We performed a comprehensive literature search of Google, Pubmed/Medline, Embase, Scopus and the Cochrane Library up to September 2015. Randomized controlled trials of bromocriptine-QR therapy in type 2 diabetes mellitus were eligible. Information was collected concerning basic study data, patient characteristics, methodological quality, efficacy and safety outcomes. There were seven randomized controlled trials on bromocriptine QR as add on therapy. All seven trials revealed a statistically significant (P < 0.05) reduction in glycemic markers in bromocriptine group. Compared to placebo group Bromocriptine-QR as add-on therapy lowered hemoglobin A1c with weighted mean difference − 0.67 , 95% CI − 0.76 to − 0.45. Similarly FBS was reduced with weighted mean difference 18mg/dl, 95% CI 14mg/dl to 23mg/dl and PPBS was reduced with weighted mean difference 28mg/dl, 95% CI 24mg/dl to 33mg/dl. Safety data show that nausea, headache, vomiting, somnolence, and hypoesthesia commonly reported (7-11%) . But they are mild and transient. Moreover Bromocriptine-QR group had no increased risk of hypoglycaemia, hypotension and positive cardiovascular effects. In conclusion bromocriptine-QR therapy offers an attractive alternative option to currently available oral anti diabetic agents for type 2 diabetes mellitus because of novel mechanism of action, good side effect profile and its effects to reduce cardiovascular event rates.

Biography:

Post graduate in kmc mangalore, final year

Abstract:

A total of 60 people with metabolic syndrome were included. Metabolic syndrome was defined as per ATP III guidelines. Hyperuricemia was defined with cutoff >6.8mg/dl in both men and women. Associated work up for metabolic syndrome and insulin resistance like FBS,FLP,FASTING INSULIN,SERUM URIC ACID was done. Blood pressure and anthropometric measurements including weight, height & waist circumferences were measured and BMI calculated. HOMA IR method was used for calculating insulin resistance. Logistic regression analysis was used to evaluate association of hyperuricemia with metabolic syndrome and insulin resistance.

Biography:

Mohammed Farhan Katheem received MSc in Advanced Biochemistry in 2007 from Thiruvalluvar University and worked as a Research Fellow at Genewin Biotech company, Hosur, TN (2007-2008). Later he joined as Research Assistant (2008-2011) with Dr.T.P.Sastry, Sr. Principal Scientist and Head of the Department, Bioproducts Laboratory. He was awarded CSIR-Senior Research Fellowship and joined the same from 2012 to till date under the guidance of Dr. A. B. Mandal, Director i/c, CSIR-CLRI and working at Bioproducts Laboratory. He has published 7 papers in national and international journals of repute and has credit of 2 patents, which was commercialized to Indian companies

Abstract:

Diabetes mellitus is a fastest growing non communicable disease in India. The bio-molecule, protein is mainly affected by diabetic condition due to presence of reactive functional groups results in glycation and aggregation. The human nail plate act as shield and it gives protection to human body and composed of hard α–keratin, which is the substance forming stratum corneum. Acceptable differences in infrared (IR) spectra of diabetic (D), prone to diabetic (PD) and non-diabetes (ND), human toe-nail specimens were investigated in this study.

Biography:

P. Hemalatha completed her M.Sc. in Bioinformatics. She is currently pursuing her doctorate degree under the guidance of Dr. Mazher Sultana. She has undergone training on genome analysis and phylogenetic studies in Akshaya Neuroinformatics Institute. She has completed course in SQL (Relational Database Management System) and also made research on drugs for polycystic ovaries.

Abstract:

As of 2013, 382 million people have diabetes worldwide. Type 2 makes up about 90% of the cases. This is equal to 8.3% of the adult population with equal rates in both women and men. In 2014, the International Diabetes Federation (IDF) estimated that diabetes resulted in 4.9 million deaths. The World Health Organization (WHO) estimated that diabetes resulted in 1.5 million deaths in 2012, making it the 8th leading cause of death. The discrepancy between the two estimates is due to the fact that cardiovascular diseases are often the cause of death for individuals with diabetes; the IDF uses modeling to estimate the amount of deaths that could be attributed to diabetes. More than 80% of diabetic deaths occur in low and middle-income countries. The aim of the project to find out the percentage of homology between the molecular gene coded proteins. We perform sequence alignment and protein 3D structure comparison using bioinformatics tools and databases. The scope of the project lies in finding out how the novel drug candidates can be applied in future clinical research studies using deliver rat model protein

Biography:

P. Hemalatha completed her M.Sc. in Bioinformatics. She is currently pursuing her doctorate degree under the guidance of Dr. Mazher Sultana. She has undergone training on genome analysis and phylogenetic studies in Akshaya Neuroinformatics Institute. She has completed course in SQL (Relational Database Management System) and also made research on drugs for polycystic ovaries.

Abstract:

As of 2013, 382 million people have diabetes worldwide. Type 2 makes up about 90% of the cases. This is equal to 8.3% of the adult population with equal rates in both women and men. In 2014, the International Diabetes Federation (IDF) estimated that diabetes resulted in 4.9 million deaths. The World Health Organization (WHO) estimated that diabetes resulted in 1.5 million deaths in 2012, making it the 8th leading cause of death. The discrepancy between the two estimates is due to the fact that cardiovascular diseases are often the cause of death for individuals with diabetes; the IDF uses modeling to estimate the amount of deaths that could be attributed to diabetes. More than 80% of diabetic deaths occur in low and middle-income countries. The aim of the project to find out the percentage of homology between the molecular gene coded proteins. We perform sequence alignment and protein 3D structure comparison using bioinformatics tools and databases. The scope of the project lies in finding out how the novel drug candidates can be applied in future clinical research studies using deliver rat model protein

Biography:

Corresponding author: Dr. Rajeev Taliyan completed his M.Pharm. (Phramacology) from Punjabi University-Patiala, Punjab and Ph.D in Pharmacology with Prof. P.L Sharma (Emiratus, Prof. PGIMER) and Late Prof. Manjeet Singh (Ex Head, Dean, Punjabi University) from ISF college, Punjab Technical University, Punjab. Currently he is working as Assistant Professor in the Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Pilani-campus, Rajasthan. His field of expertise is Cardiovascular and Neuropharmacology.

Abstract:

Recent studies have the investiagted that insulin resistance (IR) is a strong risk factor for diabetes and cerebral stroke, which are leading causes of death and long term disability. In the recent past, various studies reported that impaired GSK-3β activity was found in IR and cerebral stroke . The present study was designed to investigate the neuroprotective role of GSK-3β inhibitors against cerebral stroke and cognitive deficts in diabetic rats. IR was induced by high fat diet (HFD) and cerebral stroke was acheived by 60 min ischemia followed by 24 hours of reperfusion. To estimate motor coordination rotarod performance, actophometer test has been performed. Cognitive impairment was assessed using Y-maze task and acetylcholinesterase (AchE) activity. Biochemical estimations were done to estimate oxidative and inflammtory markers, brain insulin levels, serum glucose levels. Molecular estimation of brain derived neurotrophic factor (BDNF) levels and GSK-3β levels were also estimated. Histopathological estimation was done using hematoxylin and eosin staining. The rats subjected HFD and cerebral stroke, showed increased serum glucose and insulin levels, reduced brain insulin levels, altered motor cordination and cognition along with elevated oxidative stress and AchE activity. In addition reduced BDNF levels and high GSK-3β activity has been observed. In contrast, rats treated with GSK-3β inhibitor after IR and stroke, significantly improved behavioral and memory performance, reduced oxidative stress and inflammation, improved BDNF levels and attenuated GSK-3β activity.The current study suggest neuroprotective effect of GSK-3β inhibitor aganist cerebral stroke and associated cognitive deficts in diabetic rats.

Biography:

K. Bangaru Lalitha completed M.Phil in Bioinformatics. She is pursuing Doctorate Degree under the guidance of Dr. Mazher Sultana. She has completed training on Molecular Modeling and Drug Designing and also on Fundamentals of Nanotechnology. Her research is based on the Genetic aspects of Diabetic retinopathy.

Abstract:

Diabetic retinopathy is the result of microvascular retinal changes. Hyperglycemia-induced intramural pericyte death and thickening of the basement membrane lead to incompetence of the vascular walls. These damages change the formation of the blood-retinal barrier and also make the retinal blood vessels become more permeable. As the disease progresses, severe nonproliferative diabetic retinopathy enters an advanced, or proliferative (PDR), stage when blood vessels proliferate (i.e. grow). The lack of oxygen in the retina causes fragile, new, blood vessels to grow along the retina and in the clear, gel-like vitreous humor that fills the inside of the eye. Without timely treatment, these new blood vessels can bleed, cloud vision, and destroy the retina. Fibrovascular proliferation can also cause fractional retinal detachment. The new blood vessels can also grow into the angle of the anterior chamber of the eye and cause Neovascular glaucoma. The primary focus of the current research work is to find out to identify the predominant blood group affected by Retinopathy diabetes using clinical and statistical tools. The outcome of the project work would be useful in the field of diabetic research studies.

Biography:

I Mary Priyanka Udumula completed Bachelors of Pharmacy from kakatiya university securing 10th rank, Masters in Pharmacology from kakatiya universiity securing university 1st rank. Joined as DST inspire junior research fellow with inspire fellowship in Birla institute of Technology-PILANI, Hyderabad campus.

Abstract:

Double-stranded RNA-dependent protein kinase (PKR) is a serine/threonine protein kinase activated by various stress signals and plays an important role in obesity, insulin sensitivity and glucose homeostasis. Indirubin-3'-oxime (I3O) is an effective inhibitor of cyclin-dependent kinases (CDKs) and glycogen synthase kinase 3-beta (GSK-3). However, the effects of I3O on PKR expression and related consequences in cultured rat cardiomyocytes have not been reported. The aim of the present study was to investigate whether I3O attenuates the effects of high glucose on PKR, oxidative stress and apoptosis in cultured rat cardiac myocytes. Q- PCR, western blotting, DAPI staining and DCFDA assay were done to measure protein/mRNA expression, apoptosis and reactive oxygen species levels respectively. High glucose treatment caused significant increase in PKR mRNA expression which was attenuated by co-treatment with Indirubin-3-oxime. High glucose treated cultured cardiomyocytes developed a significant increase in mRNA expression for JNK, caspase-3 and NF-KB, which were all attenuated by pretreatment with I3O. There was also a significant increase in reactive oxygen species generation as well as apoptosis in high glucose treated cultured cardiomyocytes, which was attenuated by pretreatment with Indirubin-3-oxime. In conclusion, I3O may have a preventive role against the deleterious effects of high glucose in the heart.

Biography:

Deepak k Jumani,has completed his ASC (USA), FACS (USA), MBBS, FCGP, FIAMS, Ph D.He is Diplomate American Board Certified Clinical Sexologist.He is also an Ex Clinical Associate at the Department of Sexual Medicine of Seth GS Medical College and KEM Hospital.

Abstract:

Introduction: According to IDF (International Diabetes Federation)There are 382 Million Diabetics across the globe. One third of these Diabetics are in India, closely competing with China. So India is the Diabetes Capital of the world. The Commonest complication of Diabetes in Men is Erectile Dysfunction. So India is the Erectile Dysfunction Capital of the world.
Objectives: Since Erectile Dysfunction is the Earliest Marker of Myocardial ischaemia, Our aim is to study the prevalence of Erectile Dysfunction and detect it as early as possible in every Diabetic and promote measures to provide them adequate education, lifestyle modification and necessary medical therapy to retard the onset of critical ailments like MI or Stroke in these subjects.
Methods: 54362 patients, all diabetics, were studied, Complete detailed medical history and Sexual history was taken, Basic Investigations like Bl Sugars Fasting PP, Hba1C, Lipid Profile, Renal Functions, Liver Functions, Uric Acid , Vit D, Serum Testosterone, Free and Total, SHBG, Serum PSA Free and Total, Thyroid studies, Urine routine were done. Besides this we also did their dental examination, Digital Rectal examinations, USG of Scrotum and Penile Doppler studies and sleep studies We also did the Resting ECG and Coronary Angiogram. We also did the IIEF Scores and B Depression Scores. We gave questionnaire to 800 GPs to follow up the diabetic patients with ED after the onset of diagnosis for symptoms CAD.
Results: Over 70 percent of Male Diabetics had ED at Diagnosis. 9 years follow done and 84 percent had signs and symptoms suggestive of CAD. In Women diabetics Hypoactive Sexual Desire disorders and Depression. We compared all these results with data from China and other countries.
Conclusions: India ranks highest in the prevalence of Diabetes. in men ED is commonest complication, hence India is Erectile Dysfunction capital of the world

Biography:

Alaa shaheen has graduated from mansoura university , worked at Kafr el-sharakwa medical centre

Abstract:

There is a debate on the function of mitochondrial uncoupling protein-2 in beta cells and its involvement in palmitate-induced impairment of glucose-stimulated insulin secretion. Some investigators suggested that uncoupling protein-2 is involved in this impairment while others denied its involvement. Based on the results of their studies, this controversy can be solved by hypothesizing that palmitate-induced impairment of glucose-stimulated insulin secretion occurs in two stages, early stage and late stage, depending on the integrity of electron supply and transport system through electron transport chain after palmitate treatment. Prolonged exposure of beta cells to palmitate can impair this system.
Early stage impairment occurs due to uncoupling by uncoupling portein-2 when this system is still intact. When this system becomes impaired, late stage impairment occurs due to reduced ATP production independent of uncoupling by uncoupling protein-2. The change in glucose-stimulated oxygen uptake after palmitate treatment reflects the integrity of this system and can be used to differentiate between the two stages. Some beta-cell lines appear to be more resistant to palmitate-induced impairment of electron supply and transport system than others and therefore, early stage is prominent in the more resistant cell lines and less prominent in the less resistant cell lines.

Biography:

Dr Grace George completed her PhD in 1980 from Central Food Technological Research Institute, Mysore. India. Currently Professor and Head of the Division of Medical Biochemistry, Faculty of Health Sciences at Walter Sisulu University, South Africa. Many postgraduate students graduated under her supervision and she has several publications and presentations to her credit.

Abstract:

The metabolic derangement in diabetes mellitus lead to increased oxidative stress in the body and consequent development of the disabling chronic complications. The aim of the present study was to evaluate oxidative stress parameters and total Antioxidant status in Type 2 diabetic patients in the region and to compare it with that of healthy non diabetic controls. 57 type 2 diabetic patients and 41 normal healthy controls consented and participated in the study. Fasting blood glucose (FBS), Glycosylated haemoglobin and lipid profile were assayed by routine laboratory methods. Serum total antioxidant capacity (TAO), thiobarbituric acid reactive substances (TBARS) and the antioxidant enzyme superoxidedismutase (SOD) and Oxdidized LDL levels were measured using standard commercial reagent kits employing ELISA technique. The results expressed as mean ± SD. The results indicated statistically significant increases in FBS (p<0.000), HbA1c (p<0.000), Triglycerides (p<0.031),TBARS (p<0.004), and oxidized LDL (p<0.022) in type 2 diabetic patients as compared to control population, whereas Total antioxidant activity (p<0.010) and HDL cholesterol (p<0.008) were significantly decreased in diabetic patients. Total cholesterol, LDL cholesterol and SOD enzyme activity did not show any significant changes among both groups. Oxidative stress indicators showed positive correlation with FBS and HbA1c while there was significant negative correlation with TAO and HDL cholesterol. The above results warrant Intervention through a diet rich in antioxidants, antioxidant vitamins and life style modifications to prevent the debilitating complications of diabetes in these patients.

Biography:

Prof. Sultan Ayoub Meo is a medical graduate [MBBS] with higher postgraduate degree [M.Phil] and Doctorate [Ph.D] in Physiology. He is also a Fellow of Royal College of Physicians of Ireland [FRCP], Fellow of Royal College of Physicians of London, Glasgow and Edinburgh. In addition to achieve MBBS, M.Phil, Ph.D and FRCP of four Royal Colleges of UK and Ireland, he also obtained higher postgraduate Diploma in Medical Education, University of Dundee, Scotland UK. Prof Meo is author of 8 books and published 110 scientific papers in peer reviewed national/International prestigious bio-medical Journals.

Abstract:

Installation of Mobile Phone Base Stations in residential areas has initiated public debate about possible adverse effects on human health. This study aimed to determine the association of exposure to Radio Frequency Electromagnetic Field Radiation (RF-EMFR) generated by Mobile Phone Base Stations with glycated hemoglobin (HbA1c) and occurrence of type 2 diabetes mellitus. For this study, two different elementary schools (school 1 and school 2) were selected. We recruited 159 students in total; 96 male students from school 1, with age range 12-16 years, and 63 male students with age range 12-17 years from school 2. Mobile phone base stations with towers existed about 200 meters away from the school buildings. RF-EMFR was measured inside both schools. In school 1, RF-EMFR was 9.601 nW/cm2 at frequency of 925 MHz, and students had been exposed to RF-EMFR for a duration of 6 hours daily, 5 days in a week. In school 2, RF-EMFR was 1.909 nW/cm2 at frequency of 925 MHz and students had been exposed for 6 hours daily, 5 days in a week. 5-6 ml blood was collected from all the students and HbA1c was measured. The mean HbA1c for the students who were exposed to high RF-EMFR was significantly higher (5.44±0.22) than the mean HbA1c for the students who were exposed to low RF-EMFR (5.32±0.34) (p=0.007). Moreover, students who were exposed to high RF-EMFR generated by MPBS had a significantly higher occurrence of type 2 diabetes mellitus [P=0.0001] relative to their counterparts who were exposed to low RF-EMFR. It is concluded that exposure to high RF-EMFR generated by MPBS increase HbA1c and occurrence of type 2 diabetes mellitus among school aged adolescents.

Biography:

Abstract:

Diabetes as basically arising from imbalances in a new “fundamental set of meridians”; also crucial dependence of diabeter especially its secondary effects, on enzyme “glocose phosphatase”; also how decrease in ratio of unsaturated to saturated fats in free fatty acids is direct reason for indo-diabetes and obesity
Abstract
A Diagram – evolved from previous research in Vedic Sciences – is first presented, which shows a New Relationship, hitherto undiscovered, between a set of Meridians which may be called the “Fundamental Set of Meridians” [most of these Meridians, as presented here, are related to Pranic Chakras].
It is found that most present-day malaises which are classified by name of “DISORDERS” (ie. Which are not “Diseases” caused by infections etc.) – most notably Diabetes – depend crucially upon BALANCES between these Meridians, according to certain Fundamsntal Rules.
Short discussions will be first made, showing how Diabetes is governed strongly by Imbalances in Ajna, Solar Plexus and Navel Chakras [this is also reason why (Development of Concentration Power, thus) Meditation, Hatha Yoga and Pranayama – in turn also implying Attainment of Perfect Yogic State – are highly powerful in preventing also curing Diabetes].
The second half of discussions relates directly to Physiology, and 2 important points are made here: Firstly it is shown, through arguments in Theory of Acupuncture, how the enzyme “Glucose Phosphatase” must be a substance in body which has a direct dependence on Diabetes, it is also of crucial importance in causing most of the secondary effects of Diabetes including retinopathy, kidney stones etc. [conversely, restoring levels of glucose phosphatase to normal levels will have tremendous value in curing Diabetes]. Secondly, it is explained, based on physiological considerations, how Diabetes will very strongly depend on Ratio of Unsaturated to Saturated Fats in Free Fatty Acid, and this is the single important physiological condition which causes “Indo-Diabetes” with all its characteristics (especially of abdominal fat), it also leads directly to Obesity [this Ratio also depends on level of “Glycerol” in tissue cells and blood].

Biography:

Mrs.K.Saraswathi is working as an Assistant Professor at Nehru Memorial College , which is in Trichy District in Tamilnadu state. She has completed her B.Sc and M.Sc degree in the same College. She has got her M.Phil and M.C.A from Periyar University, Tamilnadu. She is currently pursuing her doctorate degree at Bharathiyar University under the guidance of Dr.V.Ganesh Babu,who is working as an Assistant Professor at Government College for Women in Karnataka, India.

Abstract:

Diabetic Retinopathy is a common complication of diabetes and the primary cause for visual impairment and blindness in adults that is caused by changes in the blood vessels of the retina. The symptoms can blur or distort the patient’s vision. Retinopathy is often symptomatic and the patient is unaware of retinopathy until the eyes are routinely examined or until visual impairment is detected.Regular screening is essential in order to detect the early stages of diabetic retinopathy for timely treatment to prevent further damage of vision.The retina is a unique site where the microvasculature can be directly visualized and monitored repeatedly over time. An important aspect of DR is the micro-vascular changes that cause detectable changes in the appearance of retinal blood vessels. Recent advances in retinal hotographic imaging techniques have facilitated the development of computer assisted methods to measure and quantify subtle variations and abnormalities in the retinal microvasculature. The blood vessels in the retina get altered. Exudates are secreted, micro aneurysms and hemorrhages occur in the retina. The appearance of these features represent the degree of severity of the disease.Micro aneurysms are focal dilations of retinal capillaries and appear as small round dark red dots. Haemorrhages occur when blood leaks from the damaged retinal vessels.Exudates occur when lipid or fat leaks from abnormal blood vessel or aneurysms.The different stages of Non-Proliferative Diabetic Retinopathy are detected using the features Exudates,Blood Vessels, Micro aneurysms and Haemorrhages.An early detection and diagnosis will assist in timely treatment and a reduction in the percentage of visual impairment due to these conditions, it will assist for a better treatment plan and to improve the vision related quality of life.

Biography:

Abstract:

Diabetes is characterized by near (type 1) or relative (type 2) deficiency and the regulation of β-cell mass is a critical issue in understanding the disease, when pancreatic islet regeneration can compensate the loss of functional β-cells and forms an attractive strategy for the control of diabetes. Working in this direction , we have demonstrated for the expansion and differentiation of the pancreatic progenitors such as Ductal epithelial cells(DEC)/CK-19+ve/ABCG-2 /PLP and Nestin positive cells (NPC) / ABCG-2 / RA in a STZ induced diabetic mice model system under the nutrient regulation of PLP/Vitamin B6 and all Trans Retinoic acid.The in vitro generated neoislets were functionally viable, and three weeks of post Tx almost normalized the hyperglycemic response, upregulation of key transcription factors (Pdx-1,Glu-2 and Reg, Insulin) vis a vis evidences of beta cell regeneration. Yet in another approach studies by Vikas etal (2009) and kadam et al (2011) have well documented for the differentiation potential of MSCs (adipose /& and placenta ) to generate ILCCS ,and their ability to reverse hyperglycemia in model system.Their findings are significant keeping in view that Mesenchymal stem cells (perinatal tissues,adipose derived ,Bone marrow) display remarkable immunomodulatory, reparative and anti-inflammatory properties and studies show that they augment repair process by secreting paracrine factors to modulate the milieu.With the advent of iPSCs technology, to recreate physiological milieu using adult stem cells to generate embryonic like stem cells / and their differentiation to ILCCS hold further promises of stem cells in the management of diabetes in future. Biography Dr (Mrs) Vijayalakshmi V has completed her PhD in Biochemistry (National Institute Of Nutrition) from O.U.Hyderabad and pursued postdoctoral from CCMB,Hyderabad. She is currently ,Scientist F , HOD of Biochemistry and stem cell research NIN Hyd. She has several Ph.D students and post docs working with her .She is the receipient of Prestigious senior biomedical fellow ship from ICMR ,to visit Karolinska Institute,Sweden to work in the field of diabetic research.She has to her credit several publications,contributed in text books of regenerative research,and popular articles.She has been in several committee of stem cell board,research advisory ,selection and board of studies in universities,hospital ,industry etc. Her current interst is in the field of Non –communicable diseases including diabetes.