Hemalatha P
Bharathiar University
India
Title: 3D structure comparison studies of the proteins involved in Diabetes mellitus of human beings and rat using bioinformatics methods
Biography
Biography: Hemalatha P
Abstract
As of 2013, 382 million people have diabetes worldwide. Type 2 makes up about 90% of the cases. This is equal to 8.3% of the adult population with equal rates in both women and men. In 2014, the International Diabetes Federation (IDF) estimated that diabetes resulted in 4.9 million deaths. The World Health Organization (WHO) estimated that diabetes resulted in 1.5 million deaths in 2012, making it the 8th leading cause of death. The discrepancy between the two estimates is due to the fact that cardiovascular diseases are often the cause of death for individuals with diabetes; the IDF uses modeling to estimate the amount of deaths that could be attributed to diabetes. More than 80% of diabetic deaths occur in low and middle-income countries. The aim of the project to find out the percentage of homology between the molecular gene coded proteins. We perform sequence alignment and protein 3D structure comparison using bioinformatics tools and databases. The scope of the project lies in finding out how the novel drug candidates can be applied in future clinical research studies using deliver rat model protein.