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7th Indo Global Diabetes Summit and Medicare Expo

Bengaluru, India

Naini Bhadri

Al Ameen College of Pharmacy, Dept. of Pharmacology, Bangalore

Title: Allantoin ameliorates biochemical, behavioural and electrophysiological deficit in streptozotocin (STZ) induced peripheral neuropathy in diabetic rat

Biography

Biography: Naini Bhadri

Abstract

The study was conducted to investigate the neuroprotective potential of allantoin against biochemical, behavioural and electrophysiological deficit in streptozotocin (STZ) induced peripheral neuropathy in diabetic rat. Oral administration of allantoin (100 & 200 mg/kg; per oral) began on the confirmation of diabetes after 72 hours of STZ treatment and was continued for 8 weeks in Wistar albino rats. Determination of body weight and behavioural tests were performed subsequently in every two week during allantoin treatment period. In addition sciatic nerve conduction velocity studies and biochemical parameters of nerve homogenate and serum were performed. In vitro antioxidant activity and AGE (advanced glycation end product) inhibitory assay of allantoin were also performed. Animals treated with allantoin showed a significant improvement in body weight and reduction in serum blood glucose levels as compared to vehicle-treated diabetic rats. Moreover, significant improvement was noted in hyperalgesia, grip strength muscle co-ordination and nerve conduction velocity in allantoin treated diabetic rats. In sciatic nerve there was a significant increase in MDA level and poor antioxidant levels were observed. Reduction in MDA level and NO was determined nevertheless increase in the antioxidant level was perceived in allantoin treated group. Allantoin treatment shows efficacy for preventing diabetic deterioration as seen by improvement in biochemical, behavioural and electrophysiological deficit. The neuroprotective effect of allantoin could be attributed to its anti-hyperglycemic, AGE inhibitory activity and reduction in oxidative and nitrosative stress.