Koushik Nandan Dutta
1Assam Down Town University
India
Title: Anti-diabetic activity of Sonchus asper and Sonchus arvensis leaf in alloxan induced diabetic rats
Biography
Biography: Koushik Nandan Dutta
Abstract
Diabetes mellitus (DM) is a chronic disease caused by inherited or acquired deficiency in production of insulin by the pancreas, or by the ineffectiveness of the insulin produced. India has today become the diabetic capital worldwide over 20million diabetes and this number is set to increase to 57 million by 2025. Decreased physical activity, increasing obesity, stress and changes in food consumption is the main reason for causing Diabetes mellitus. Though different types of oral hypoglycemic agents are available along with insulin for the treatment of diabetes, there is an increase demand by patients to use natural products with anti-diabetic activity. The present study was carried out to investigate the anti-diabetic potential of ethanolic extract of the leaves of Sonchus asper (Family- Asteraceae) and Sonchus arvensis (Family-Asteraceae). Oral administration of ethanol extract in the doses of 100, 150 & 200 mg/kg body weight to white Wistar rats significantly reduced their blood sugar level in alloxon induced diabetic rats under acute and sub-acute studies. The results showed that the ethanol extract doses of 200mg/kg b-wt have significant anti-hyperglycemic effect in experimental model of diabetes mellitus. Based on the results, it can be reasonably concluded that both Sonchus species has antidiabetic activity. This study also becomes a valuable reference for further research.