Rachita Nanda
Department of Biochemistry,AIIMS,India
Title: HEAT SHOCK PROTEINS IN DIABETES MELLITUS
Biography
Biography: Rachita Nanda
Abstract
Molecular chaperones play a role in folding of nascent polypeptides into their biologically active structures. Also known as heat shock proteins(HSP), they respond to a wide variety of stress protecting the cell and their organelles against many chronically and acutely stressful conditions. Activation of HSP results in stress tolerance and also protection against stress induced molecular damage. Obesity which is associated with diabetes is linked to a state of chronic inflammation. Therein occurs release of various cytokines which lead to insulin resistance. With an ever continuing rise of diabetes which is snowballing into an epidemic, chaperone proteins have been implicated in blocking inflammation and thus in the treatment of insulin resistance and obesity associated with type 2 diabetes mellitus.