Clinical Diabetes and Diagnostic Approaches

Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. The chronic hyperglycemia of diabetes is associated with long-term damage, dysfunction, and failure of various organs, especially the eyes, kidneys, nerves, heart, and blood vessels.

Diabetic kidney disease is recognized as the leading cause of excess mortality in the population with type 1 diabetes. The prevailing theory is that excess calories are processed via the mitochondria resulting in accumulation of superoxide radicals via the electron transfer chain. Novel Paradigms in Diabetic Complications, Diabetes, Pre-diabetes represents an elevation of plasma glucose above the normal range but below that of clinical diabetes. Prediabetes and Metabolic Syndrome, To better study both the pathogenesis and potential therapeutic agents, appropriate animal models of type 2 diabetes (T2D) mellitus are needed  for Clinical trials on animal models,  sodium glucose co-transport inhibitors act as a novel strategy for the treatment of diabetes mellitus

Type 2 diabetes is by far the most common type of diabetes in adults (>90 percent) and is characterized by hyperglycemia and variable degrees of insulin deficiency and resistance in Clinical presentation and diagnosis of diabetes mellitus in adults.

Related conferences:

20th World Summit on Diabetes, Nutrition, Metabolism & Medicare July 24-26,2017 Vancouver, Canada; 23rd International Conference on Herbal and Alternative Remedies for Diabetes and Endocrine Disorders November 2-4, 2017 Bangkok, Thailand; 18th European Diabetes Congress July 17-18, 2017 Lisbon, Portugal; 10th Diabetologists Conference July 24-26,2017 Vancouver, Canada; 19th Asia Pacific Diabetes Conference July 20-22, 2017 Melbourne, Australia;7th European Diabetes and Endocrinology Congress May 18-19,2017 Munich, Germany ; 16th Global Diabetes Conference & Medicare Expo March 22-23, 2017 Rome, Italy; 8th International Conference on Adrenal & Thyroid Disorders, Treatment June 12-13, 2017 Taiwan, Taipei; 13th World Congress on Diabetes  October 05-06, 2017 London,UK; 12th International Conference on Endocrinology and Diabetes Summit November 06-07, 2017 Singapore.

 Diabetes Management

People with type 1 or type 2 diabetes are diagnosed with more of some types of cancer -- and are more likely to die from cancer -- than people without diabetes, a new Australian study shows.

The brain is a hugely important organ which helps to be aware of, understand and interact with our surroundings and others.

As with many of our organs, the brain is susceptible to damage as a result of diabetes & brain

Diabetes foot care & management: Foot ulcers and amputations are a major cause of morbidity, disability, as well as emotional and physical costs for people with diabetes. Early recognition and management of independent risk factors for ulcers and amputations can prevent or delay the onset of adverse outcomes.

In Cardiac Resynchronization Therapy Arrhythmias are irregular heart rhythms and can be caused by a variety of reasons, including age, heart damage, medications and genetics. In heart failure patients CRT, or biventricular pacing, is used to help improve the heart’s rhythm and the symptoms associated with the arrhythmia.

Implantable Cardioverter Defibrillator An ICD is a battery-powered device placed under the skin that keeps track of your heart rate. Thin wires connect the ICD to your heart. If an abnormal heart rhythm is detected the device will deliver an electric shock to restore a normal heartbeat if your heart is beating chaotically and much too fast. It is important to understand that the decision to have angioplasty or coronary artery bypass graft (CABG) surgery to treat coronary artery disease (CAD) depends on many different things. A healthful eating pattern, regular physical activity, and often pharmacotherapy are key components of diabetes management. It is best to get vitamins and minerals from the foods you eat. In fact, research has not been able to prove that dietary or herbal supplements (including omega-3 supplements, cinnamon, and other herbs) help to manage diabetes.

Related conferences:

19th Asia Pacific Diabetes Conference July 20-22, 2017 Melbourne, Australia;7th European Diabetes and Endocrinology Congress May 18-19,2017 Munich, Germany ; 16th Global Diabetes Conference & Medicare Expo March 22-23, 2017 Rome, Italy; 8th International Conference on Adrenal & Thyroid Disorders, Treatment June 12-13, 2017 Taiwan, Taipei; 13th World Congress on Diabetes  October 05-06, 2017 London,UK; 12th International Conference on Endocrinology and Diabetes Summit November 06-07, 2017 Singapore;20th World Summit on Diabetes, Nutrition, Metabolism & Medicare July 24-26,2017 Vancouver, Canada; 23rd International Conference on Herbal and Alternative Remedies for Diabetes and Endocrine Disorders November 2-4, 2017 Bangkok, Thailand; 18th European Diabetes Congress July 17-18, 2017 Lisbon, Portugal; 10th Diabetologists Conference July 24-26,2017 Vancouver, Canada

Diabetes and its complications

Gastro paresis is a disorder affecting people with both type 1 and type 2 diabetes in which the stomach takes too long to empty its contents (delayed gastric emptying) Diabetic retinopathy is the most common diabetic eye disease and a leading cause of blindness in American adults. It is caused by changes in the blood vessels of the retina. Diabetic neuropathy is a type of nerve damage that can occur if you have diabetes. High blood sugar can injure nerve fibers throughout your body, but diabetic neuropathy most often damages nerves in your legs and feet. Currently, diabetic nephropathy is the leading cause of chronic kidney disease in the United States and other Western societies. It is also one of the most significant long-term complications in terms of morbidity and mortality for individual patients with diabetes. Diabetes is responsible for 30-40% of all end-stage renal disease (ESRD) cases in the United States.

Cardiomyopathy is a condition where the heart muscle is abnormal. The main types of cardiomyopathy include dilated, hypertrophic and restrictive cardiomyopathy. Cardiomyopathy makes it harder for your heart to pump and deliver blood to the rest of your body. Cardiomyopathy can lead to heart failure. Latent autoimmune diabetes in adults (LADA) is a disorder in which, despite the presence of islet antibodies at diagnosis of diabetes, the progression of autoimmune β-cell failure is slow.

Hypoglycemia is a medical emergency that involves an abnormally diminished content of glucose in the blood. Pregnant women who have never had diabetes before but who have high blood glucose (sugar) levels during pregnancy are said to have gestational diabetes. According to a 2014 analysis by the Centers for Disease Control and Prevention, the prevalence of euglycemia gestational diabetes conferences is as high as 9.2%.  High blood pressure or hypertension increases the risk of heart disease and stroke. Hypertension risk factors include obesity, drinking too much alcohol, smoking, and family history. Beta-blockers are a common treatment for hypertension.

Related conferences:

13th World Congress on Diabetes  October 05-06, 2017 London,UK; 12th International Conference on Endocrinology and Diabetes Summit November 06-07, 2017 Singapore;20th World Summit on Diabetes, Nutrition, Metabolism & Medicare July 24-26,2017 Vancouver, Canada; 23rd International Conference on Herbal and Alternative Remedies for Diabetes and Endocrine Disorders November 2-4, 2017 Bangkok, Thailand; 18th European Diabetes Congress July 17-18, 2017 Lisbon, Portugal; 10th Diabetologists ConferenceJuly 24-26,2017 Vancouver, Canada; 19th Asia Pacific Diabetes Conference July 20-22, 2017 Melbourne, Australia;7th European Diabetes and Endocrinology Congress May 18-19,2017 Munich, Germany ; 16th Global Diabetes Conference & Medicare Expo March 22-23, 2017 Rome, Italy; 8th International Conference on Adrenal & Thyroid Disorders, Treatment June 12-13, 2017 Taiwan, Taipei;

Advanced Technologies & Treatments for Diabetes

Blood glucose (blood sugar) monitoring is the main tool you have to check your diabetes control. This check tells you your blood glucose level at any one time. The artificial pancreas bridges the gap between two pieces of diabetes technology that already exist: the insulin pump and the continuous glucose monitor (CGM). Relatively, a large percentage of world population is affected by diabetes mellitus, out of which approximately 5-10% with type 1 diabetes while the remaining 90% with type 2. Insulin administration is essential for type 1 patients while it is required at later stage by the patients of type 2. Current insulin delivery systems are available as transdermal injections which may be considered as invasive. Several non-invasive approaches for insulin delivery are being pursued by pharmaceutical companies to reduce the pain, and hypoglycemic incidences associated with injections in order to improve patient compliance.

Related conferences:

7th European Diabetes and Endocrinology Congress May 18-19,2017 Munich, Germany ; 16th Global Diabetes Conference & Medicare Expo March 22-23, 2017 Rome, Italy; 8th International Conference on Adrenal & Thyroid Disorders, Treatment June 12-13, 2017 Taiwan, Taipei;20th World Summit on Diabetes, Nutrition, Metabolism & Medicare July 24-26,2017 Vancouver, Canada; 23rd International Conference on Herbal and Alternative Remedies for Diabetes and Endocrine Disorders November 2-4, 2017 Bangkok, Thailand; 18th European Diabetes Congress July 17-18, 2017 Lisbon, Portugal; 10th Diabetologists ConferenceJuly 24-26,2017 Vancouver, Canada; 19th Asia Pacific Diabetes Conference July 20-22, 2017 Melbourne, Australia; 13th World Congress on Diabetes  October 05-06, 2017 London,UK; 12th International Conference on Endocrinology and Diabetes Summit November 06-07, 2017 Singapore.

Advancement of New Drug/Biomarker Discovery for Treatment of Diabetes

As a prognostic biomarker for progression of diabetic nephropathy, albuminuria fails in terms of sensitivity and specificity. Better urinary or plasma biomarkers are needed that can predict which diabetic patients are at highest risk for progression. Bhensdadia et al. report proteomic investigations that identified urinary haptoglobin as a potential prognostic biomarker for progressive diabetic nephropathy. Although as a single marker urinary haptoglobin adds little to albuminuria, together the two appear to provide better diagnostic accuracy than albuminuria alone. Excess adiposity is the most important risk factor for the development of insulin resistance and type 2 diabetes (1). However, mechanisms whereby body fat induces insulin resistance in distant tissues are not well understood. Recent evidence indicates that obesity may be an  inflammatory markers.

Related conferences

12th International Conference on Endocrinology and Diabetes Summit November 06-07, 2017 Singapore;20th World Summit on Diabetes, Nutrition, Metabolism & Medicare July 24-26,2017 Vancouver, Canada;  10th Diabetologists Conference July 24-26,2017 Vancouver, Canada; 19th Asia Pacific Diabetes Conference July 20-22, 2017 Melbourne, Australia;7th European Diabetes and Endocrinology Congress May 18-19,2017 Munich, Germany ; 16th Global Diabetes Conference & Medicare Expo March 22-23, 2017 Rome, Italy; 23rd International Conference on Herbal and Alternative Remedies for Diabetes and Endocrine DisordersNovember 2-4, 2017 Bangkok, Thailand; 18th European Diabetes Congress July 17-18, 2017 Lisbon, Portugal;8th International Conference on Adrenal & Thyroid Disorders, Treatment June 12-13, 2017 Taiwan, Taipei; 13th World Congress on Diabetes  October 05-06, 2017 London,UK.

Genetics of Diabetes

Several factors have to come together for a person to develop type 2 diabetes. Elements like nutrition and exercise are extremely important. However, type 2 diabetes also has a strong genetic component. Diabetes constitutes a major public health problem. Although substantial progress has been made in defining the genetic risk for specific subtypes of diabetes

The burden of diabetes is much higher for racial/ethnic minorities than for whites. Minorities have a higher prevalence of diabetes than whites, and some minorities have higher rates of diabetes-related complications and death. Research results help in understanding these disparities and ways to reduce them.

Diabetes, the sixth leading cause of death in the United States, is a chronic disease characterized by persistent hyperglycemia (high blood glucose levels). Significant advances have been made in recent years in relation to the pathogenesis of T2DM. This has significantly improved our knowledge of one of the most serious health threats in the world, allowing identification of genes and pathways involved in the development and progression of the disease. It has recently become possible to acquire molecular and genetic level information from an individual.

Related conference:

19th Asia Pacific Diabetes Conference July 20-22, 2017 Melbourne, Australia;7th European Diabetes and Endocrinology Congress May 18-19,2017 Munich, Germany ; 16th Global Diabetes Conference & Medicare Expo March 22-23, 2017 Rome, Italy; 23rd International Conference on Herbal and Alternative Remedies for Diabetes and Endocrine Disorders November 2-4, 2017 Bangkok, Thailand;12th International Conference on Endocrinology and Diabetes Summit November 06-07, 2017 Singapore; 20th World Summit on Diabetes, Nutrition, Metabolism & Medicare July 24-26,2017 Vancouver, Canada; 10th Diabetologists Conference July 24-26,2017 Vancouver, Canada; 18th European Diabetes Congress July 17-18, 2017 Lisbon, Portugal; 8th International Conference on Adrenal & Thyroid Disorders, Treatment June 12-13, 2017 Taiwan, Taipei; 13th World Congress on Diabetes  October 05-06, 2017 London,UK.

Emerging Focus in Diabetes Research

Dyslipidemia is one of the major risk factors for cardiovascular disease in diabetes mellitus. The characteristic features of diabetic dyslipidemia are a high plasma triglyceride concentration, low HDL cholesterol concentration and increased concentration of small dense LDL-cholesterol particles.

There are many risk factors for type 2 diabetes such as age, race, pregnancy, stress, certain medications, genetics or family history,  high cholesterol and obesity. However, the single best predictor of type 2 diabetes is overweight or obesity. Almost 90% of people living with type 2 diabetes are overweight or have obesity. People who are overweight or have obesity have added pressure on their body's ability to use insulin to properly control blood sugar levels, and are therefore more likely to develop diabetes. The number of diabetes cases among American adults increased by a third during the 1990s, and additional increases are expected. This rapid increase in the occurrence of diabetes is mostly attributed to the growing prevalence of obesity in the United States.

The Bioinformatics/Computational Biology Service branch will provide basic capabilities to the Joslin Diabetes Center to analyze a wide range of high-throughput data. Housed on-site at the Joslin, the group and associated resources will be available to Joslin investigators and fellows who are either planning high-throughput experiments or need analysis of multi-scale data.

We prospectively followed 51,552 Finnish men and women 25–74 years of age without a history of Parkinson's disease at baseline. History of diabetes and other study parameters were determined at baseline using standardized measurements. Ascertainment of the Parkinson's disease status was based on the nationwide Social Insurance Institution's drug register data. Hazard ratios of incident Parkinson's disease associated with the history of type 2 diabetes were estimated. The entire spectrum of diabesity, including all of its complications–diabetes, elevated blood sugar, blood pressure, and cholesterol–are simply downstream symptoms that result from problems with diet, lifestyle, and environmental toxins interacting with our unique genetic susceptibilities. Bariatric surgery may be an option for adults with severe obesity. Body mass index (BMI), a measure of height in relation to weight, is used to define levels of obesity. Clinically severe obesity is a BMI > 40 or a BMI > 35 with a serious health problem linked to obesity. Such health problems could be type 2 diabetes, heart disease, or severe sleep apnea (when breathing stops for short periods during sleep).

Related conferences:

10th Diabetologists Conference July 24-26,2017 Vancouver, Canada; 19th Asia Pacific Diabetes Conference July 20-22, 2017 Melbourne, Australia;7th European Diabetes and Endocrinology Congress May 18-19,2017 Munich, Germany ; 16th Global Diabetes Conference & Medicare Expo March 22-23, 2017 Rome, Italy; 8th International Conference on Adrenal & Thyroid Disorders, Treatment June 12-13, 2017 Taiwan, Taipei;13th World Congress on Diabetes  October 05-06, 2017 London,UK; 12th International Conference on Endocrinology and Diabetes Summit November 06-07, 2017 Singapore; 20th World Summit on Diabetes, Nutrition, Metabolism & Medicare July 24-26,2017 Vancouver, Canada; 23rd International Conference on Herbal and Alternative Remedies for Diabetes and Endocrine Disorders November 2-4, 2017 Bangkok, Thailand; 18th European Diabetes Congress July 17-18, 2017 Lisbon, Portugal.

Transplantation for Diabetes

In pancreatic islet transplantation, cells are taken from a donor pancreas and transferred into another person. Once implanted, the new islets begin to make and release insulin. Researchers hope that islet transplantation will help people with type 1 diabetes live without daily injections of insulin. Xenotransplantation is the transplantation of living cells, tissues or organs from one species to another. Such cells, tissues or organs are called xenografts or xenotransplants.

A transplant of the pancreas is usually reserved for those with serious complications. Pancreas transplants are most often done when a patient also receives a new kidney. Beta cell regeneration events pancreas transplant adds little further risk in this situation and offers big benefits. However, transplant surgery is risky. Each person needs to carefully weigh the potential benefits and risks.

Related conferences:

18th European Diabetes Congress July 17-18, 2017 Lisbon, Portugal; 8th International Conference on Adrenal & Thyroid Disorders, Treatment June 12-13, 2017 Taiwan, Taipei;19th Asia Pacific Diabetes Conference July 20-22, 2017 Melbourne, Australia;7th European Diabetes and Endocrinology Congress May 18-19,2017 Munich, Germany ; 16th Global Diabetes Conference & Medicare Expo March 22-23, 2017 Rome, Italy; 23rd International Conference on Herbal and Alternative Remedies for Diabetes and Endocrine Disorders November 2-4, 2017 Bangkok, Thailand;12th International Conference on Endocrinology and Diabetes Summit November 06-07, 2017 Singapore;20th World Summit on Diabetes, Nutrition, Metabolism & Medicare July 24-26,2017 Vancouver, Canada;  10th Diabetologists Conference July 24-26,2017 Vancouver, Canada; 13th World Congress on Diabetes  October 05-06, 2017 London,UK.

Endocrinology: Disorders & Treatment

The endocrine system is a network of glands that produce and release hormones that help control many important body functions, especially the body's ability to change calories into energy that powers cells and organs. The endocrine system influences how your heart beats, how your bones and tissues grow, even your ability to make a baby. It plays a vital role in whether or not you develop diabetes, thyroid disease, growth disorders, sexual dysfunction, and a host of other hormone-related disorders.

Related conferences:

7th European Diabetes and Endocrinology Congress May 18-19,2017 Munich, Germany; 16th Global Diabetes Conference & Medicare Expo March 22-23, 2017 Rome, Italy;18th European Diabetes Congress July 17-18, 2017 Lisbon, Portugal;8th International Conference on Adrenal & Thyroid Disorders, Treatment June 12-13, 2017 Taiwan, Taipei;19th Asia Pacific Diabetes Conference July 20-22, 2017 Melbourne, Australia;23rd International Conference on Herbal and Alternative Remedies for Diabetes and Endocrine Disorders November 2-4, 2017 Bangkok, Thailand;12th International Conference on Endocrinology and Diabetes Summit November 06-07, 2017 Singapore; 20th World Summit on Diabetes, Nutrition, Metabolism & Medicare July 24-26,2017 Vancouver, Canada; 10th Diabetologists Conference July 24-26,2017 Vancouver, Canada; 13th World Congress on Diabetes  October 05-06, 2017 London,UK.

Cell Therapy for Diabetes and Its Complications

Pancreatic β-cells are the target of an autoimmune assault in type 1 diabetes, with invasion of the islets by mononuclear cells in an inflammatory reaction termed “insulitis,” leading to loss of most β-cells after prolonged periods of disease.

Stem cells are essentially undifferentiated cells that can be induced into becoming specialized cells that are tissue- or organ-specific, according to the U.S. National Institutes of Health.

In some cases, such cells are sourced from embryonic tissue. Alternatively, it's possible to derive stem cells from prespecialized adult cells that are then reprogrammed to morph into an undifferentiated state. These are called induced pluripotent stem cells.

Related conferences:

10th Diabetologists Conference July 24-26,2017 Vancouver, Canada;7th European Diabetes and Endocrinology Congress May 18-19,2017 Munich, Germany ; 16th Global Diabetes Conference & Medicare Expo March 22-23, 2017 Rome, Italy;18th European Diabetes Congress July 17-18, 2017 Lisbon, Portugal;8th International Conference on Adrenal & Thyroid Disorders, Treatment June 12-13, 2017 Taiwan, Taipei;19th Asia Pacific Diabetes Conference July 20-22, 2017 Melbourne, Australia;23rd International Conference on Herbal and Alternative Remedies for Diabetes and Endocrine Disorders November 2-4, 2017 Bangkok, Thailand;12th International Conference on Endocrinology and Diabetes Summit November 06-07, 2017Singapore;20th World Summit on Diabetes, Nutrition, Metabolism & Medicare July 24-26,2017 Vancouver, Canada;13th World Congress on Diabetes  October 05-06, 2017 London,UK.