Gianina Ioana Constantin
National Institute of Gerontology and Geriatrics Bucharest, Romania
Title: Assessment of myeloperoxidase levels in elderly patients with type 2 diabetes mellitus
Biography
Biography: Gianina Ioana Constantin
Abstract
Background: Diabetes is a chronic condition that results in excessive blood sugar circulation, which can lead to disorders of the circulatory, nervous, and immune systems.
Many studies have shown that myeloperoxidase (MPO), a heme protein released by leukocytes, is involved in the process of oxidative stress and plays an important role in the initiation and progression of acute and chronic inflammatory diseases, suggesting a positive correlation between activation of MPO and metabolic disorders.
Purpose: Our study was proposed to assess levels of myeloperoxidase in two groups of elderly patients (69.15 ± 7.33 years): a group of control patients and a group of patients with type 2 diabetes.
Methods: MPO levels were determined in serum by immunoenzymatic assay and spectrophotometric detection at 450 nm.
Results: In this study, serum MPO concentration was demonstrated to be significantly higher in diabetic patients compared with non-diabetic group (625 ± 252.83 vs 436.66 ± 89.62 ng / ml serum).
Conclusions: In conclusion, patients with type 2 diabetes had increased serum MPO levels, wich proves that MPO, being an pro-inflammatory enzyme, can be considered an early biomarker and indicator for inflammation associated with metabolic disorders in diabetic patients.