29^th European Diabetes Congress June 15-16, 2020 Barcelona, Spain

Biography:

Audrey Boulier joined INGREDIA SA in 2012 after graduating from AgroParisTech, Leading French engineering Institute of Science and Food Industry Master’s degree. Currently working as Scientific and Innovative Manager for Bioactive, she manages the bioactive and nutrition scientific programs. In addition to innovative manager responsibilities, Mrs Boulier works in connections with Universities, Hospitals and Scientific Institutes in Europe. Before working for INGREDIA SA, Mrs Boulier was graduated from AgroParisTech, Leading French engineering Institute of Science and Food Industry; with a speciality on Biology Sciences and technology, Nutrition and Human food.

Abstract:

The study was designed to evaluate the dose-effect of PEP2DIA, a patented milk protein hydrolysate on glycemic control of type 2 diabetic Goto-Kakizaki (GK) rats treated for 6 weeks from weaning. The 6 week-treatment with PEP2DIA (63mg/kg, 88.6mg/kg and 126mg/kg) did not decrease fasting plasma glucose of GK rats, but improved sucrose tolerance with the best effect at the dose of 63mg/kg. Insulin response to sucrose was lower than control after PEP2DIA treatment at all the doses tested with the strongest decrease with 63mg/kg of PEP2DIA. This decrease in insulin response seems to be at least in part the consequence of an improvement of the insulin resistance of the GK rats. At the lowest dose tested (63mg/kg), FAS and SREBP-1c gene expressions were significantly decreased in retroperitoneal adipose tissue of GK rats, suggesting that PEP2DIA inhibited lipogenesis. PEP2DIA treatment induced strong increases in GLP-1 plasma level at all the doses tested but the difference reached significance only with 63 and 126mg/kg of PEP2DIA. This effect was not the consequence of an inhibition of DPP-4. An inhibition of alpha-glucosidase in duodenum but not in jejunum was observed after the 6-weektreatment with PEP2DIA, maybe due to a too short time after compound administration for organ sampling. Moreover, in retroperitoneal adipose tissue but not in liver, PEP2DIA at the lowest dose tested (63mg/kg), significantly decreased gene expression of both SREBP-1c and FAS, suggesting a beneficial effect on triglyceride accumulation in adipose tissue

Biography:

Dr Yusra Amanullah is a junior doctor currently working as a Foundation Year 2 at Queens Hospital Burton, University Hospitals of Derby and Burton Trust. She has completed her Foundation Year 1 training at University Hospitals of North Midlands (UHNM) 2018-2019. She graduated from Army Medical College, National University of Medical Sciences (NUMS) Pakistan in 2017.  Dr Amanullah has strong communication and presentation skills, has conducted a quality improvement project/audit and has published a case report in the Journal of Postgraduate Medical Institute (JPMI) Peshawar Pakistan at her credit

Abstract:

Approximately 80-million Muslims with type 2 diabetes fast annually during Ramadan. This study aims to determine the effects of Ramadan Specifiec Diabtes Education (RSDE) on glycaemic control of patients with Type 2 Diabetes (T2DM).

A prospective cohort study of 437 outpatients was carried out in the Abaseen Institute of Medical Sciences Sugar Hospital Pakistan from April to August 2019. A month before Ramadan, the intervention group of 238 subjects (54%) received one to one RSDE sessions. This was in addition to information leaflets; treatment adjustment plans and a questionnaire which were provided to the control group of 199 subjects (46%). International Diabetes Federation - Diabetes and Ramadan risk stratification guidelines³ were applied. Both groups had their HbA1c levels measured before and after Ramadan.

The gender distribution and mean age (50 S.D. ± 10 years) in both groups were similar. The mean reduction in HbA1c levels for the intervention and control group was (0.3 S.D. ± 0.9) % and (0.7 S.D. ± 1.5) %, respectively with (independent-samples t-test p-value < 0.001). Based on the IDF-DAR risk stratification, the intervention group consisted of 82 (34%) low or moderate risk, 146 (61%) high risk and 10 (4.2%) very high-risk subjects. The mean reductions of HbA1c in these three groups were (0.0 SD ±0.0) %, (0.4 SD 1.0) % and (0.3 SD 0.8) %, respectively with (ANOVA test p-value < 0.001).

Post Ramadan, both groups showed reduction in HbA1c levels. The control group had a greater reduction which was statistically significant.

Biography:

Huabin Wang graduated in Clinical Laboratory Diagnostics from Tianjin Medical University in 2015. He works in Central Laboratory, Jinhua Municipal Central Hospital, and commits to the clinical research on the biomarkers for early screening of diabetic kidney disease. He has published more than 10 papers in reputed journals and has been a peer reviewer for several journals

Abstract:

Early screening of diabetic kidney disease (DKD) remains a major challenge. Our aim was to evaluate the value of urinary orosomucoid 1 protein (UORM1) in early renal impairment screening in type-2 diabetes patients. Methods: The concentration of UORM1, the UORM1-to-creatinine ratio (UORM1CR), the urinary albumin-to-creatinine ratio (ACR), the alpha-1-microglobulin-to-creatinine ratio (A1MCR), and eGFR were measured in 406 type-2 diabetes patients. Any positive values for ACR, A1MCR, and/or eGFR were considered as indicative of renal impairment. Results: On average, the levels of UORM1 and UORM1CR were about 7-times higher in subjects with renal injury than in those without. Both UORM1 and UORM1CR, when adjusted via logarithm-transformation, were significantly related to ACR, A1MCR, and eGFR levels. The highest correlation was observed between UORM1CR and A1MCR (r = 0.85, P < 0.001). The cut-off values for UORM1 (2.53 mg/L) and UORM1CR (3.69 mg/g) for the early diagnosis of kidney impairment were obtained from receiver operating characteristic curves. UORM1CR obviously had higher diagnostic efficiency corresponding to 83.26% sensitivity and 90.32% specificity than UORM1. Likewise, its sensitivity was higher than those of ACR, A1MCR and eGFR. Bad glycemic control had the highest risk of increased UORM1CR (odds ratio (OR) = 2.81, P < 0.001), while high HDL-C (high-density lipoprotein cholesterol) decreased the risk of increased UORM1CR. Conclusion: UORM1CR (> 3.69 mg/g) has the high diagnostic efficiency for the early screening of renal impairment in type-2 diabetes patients. Furthermore, good glycemic control and high HDL-C might be protective factors against UORM1CR increase

Biography:

Teodora Stankova is currently a PhD student and an assistant professor in the Department of Biochemistry, Medical University – Plovdiv, Bulgaria. She graduated in Pharmacy with honours from the same university. So far, she has taken part in 4 scientific projects and more than 20 scientific conferences and workshops. She has published more than 15 papers.

Abstract:

Carbamylation of LDL is a nonenzymatic posttranslational modification of LDL resulting from addition of urea-derived cyanate to either the N-terminus or ε-amino group of lysine residues in apolipoprotein B. Carbamylated LDL (cLDL) has been recently shown to manifest all of the biological effects relevant to atherosclerosis, including endothelial dysfunction, expression of adhesion molecules and vascular smooth muscle cell proliferation. In addition, cLDL binds to macrophage scavenger receptors inducing cholesterol accumulation, foam cell formation as well as enhanced oxidant generation. Despite the discovery of an alternative urea-independent myeloperoxidase-mediated mechanism for carbamylation, cLDL has been studied only in subjects with end stage renal disease. Elevated circulating and intraintimal cLDL levels have been associated with increased cardiovascular risk in those patients. However, other carbamylation products have been delineated as independent risk markers for cardiovascular disease even in the absence of uremia. Although diabetes mellitus is characterized by an increased atherosclerotic risk, chronic low grade inflammation and increased levels of myeloperoxidase, the data on cLDL in diabetes are scarce.

Therefore, the present review reveals the main molecular mechanisms involved in the carbamylation of LDL in diabetes mellitus and briefly describes the atherogenic effects of cLDL. The possibility of using the high levels of cLDLs as a predictive tool for cardiovascular risk in diabetes-related pathologies is also discussed.

Biography:

Ping Li is the chairman of Beijing Key Lab for Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Science, China-Japan Friendship Hospital. She has engaged in the clinical and basic research of integrated traditional Chinese and western medicine treating kidney disease for 36 years and successively presided over and undertook more than 20 national and provincial level scientific research projects. She has won the second prize of national science and technology progress award and 11 prizes above provincial and ministerial level as the first accomplisher. She has obtained 5 national invention patents. She has published more than 200 papers in journals and academic conferences at home and abroad, of which more than 80 papers are included in SCI. She wrote 11 academic works and edited 5 academic works.

Abstract:

Podocyte injury is an important pathogenesis step causing proteinuric kidney diseases such as diabetic kidney disease (DKD). Actin cytoskeleton rearrangement in podocyte induced by multiple pathogenic factors is believed the key process resulting into its injury. Many studies have recently shown that transient receptor potential canonical channel 6 (TRPC6) in podocyte plays a critical role in the development and progression of proteinuric kidney disease, that participate in proteinuria formation by regulating its actin cytoskeleton rearrangement. This review aims to summarize the TRPC6 role in podocyte on DKD by regulating the actin cytoskeleton rearrangement, thereby help further broaden our views and understanding on the mechanism of DKD and provide a theoretic basis for exploring new therapeutic targets for DKD patients.

Biography:

Yuyang Wang is a PhD student in China-Japan Friendship Hospital, and she will get her PhD at the age of 28 years from China Academy of Chinese Medical Sciences, Beijing, China. She has published 2 papers in reputed journals.

Abstract:

Diabetic kidney disease (DKD), a leading cause of end-stage renal disease (ESRD), has become a serious public health problem worldwide and lacks effective therapies due to its complex pathogenesis. Recent studies suggested defective autophagy involved in the pathogenesis and progression of DKD. Chinese herbal medicine, as an emerging option for the treatment of DKD, could improve diabetic kidney injury by activating autophagy. In this review, we briefly summarize underlying mechanisms of autophagy dysregulation in DKD, including AMP-activated protein kinase (AMPK), the mechanistic target of rapamycin (mTOR), and the sirtuin (Sirt) pathways, and we particularly concentrate on the current status of Chinese herbal medicine treating DKD by regulating autophagy. The advances in our understanding regarding the treatment of DKD via regulating autophagy with Chinese herbal medicine will enhance the clinical application of Chinese medicine as well as discovery of novel therapeutic agents for diabetic patients

Biography:

Ping Li is the chairman of Beijing Key Lab for Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Science, China-Japan Friendship Hospital. She has engaged in the clinical and basic research of integrated traditional Chinese and western medicine treating kidney disease for 36 years and successively presided over and undertook more than 20 national and provincial level scientific research projects. She has won the second prize of national science and technology progress award and 11 prizes above provincial and ministerial level as the first accomplisher. She has obtained 5 national invention patents. She has published more than 200 papers in journals and academic conferences at home and abroad, of which more than 80 papers are included in SCI. She wrote 11 academic works and edited 5 academic works

Abstract:

Tangshen formula (TSF), a formula of Chinese herbal medicine, improves lipid metabolism in humans and animals with diabetic kidney disease. However, the effect and mechanism of TSF on nonalcoholic fatty liver disease (NAFLD) remain unclear. The activation of autophagy appears to be a potential mechanism for improving NAFLD. In the present study, we examined the therapeutic effect of TSF on hepatic steatosis and sought to explore whether its effect is related to activating autophagy. Here, we showed that TSF treatment signifificantly attenuated hepatic steatosis in both high-fat diet (HFD) and methionine choline-defificient diet (MCDD)-fed mice. Meanwhile, TSF reduced lipid accumulation in palmitate (PA)-stimulated HepG2 cells and primary mouse hepatocytes. Furthermore, TSF increased Sirtuin 1 (SIRT1) expression and promoted autophagy activation in vivo. TSF also improved PA-induced suppression of both SIRT1 expression and SIRT1-dependent autophagy, thereby alleviating intracellular lipid accumulation in vitro. In addition, TSF increased SIRT1 expression and induced autophagy in an adenosine monophosphate-activated protein kinase (AMPK)-dependent manner. Moreover, SIRT1 knockdown abolished the autophagy-inducing and lipid-lowering effects of TSF. In conclusion, TSF improved lipid accumulation and hepatic steatosis by inducing the AMPK/SIRT1 pathway-mediated autophagy.

Biography:

Amanda Macdonald has completed a BA in Social Sciences from McMaster University in 2018. She is currently working in the healthcare field as a Pharmacy Technician since 2018, and is working with NextGenU.org as a course creator since 2019. Her current project focuses on Diabetes education to create a course accessible from anywhere in the world for free, to facilitate better communication and education surrounding patient management of diabetes mellitus.  

Abstract:

Diabetes Mellitus is a global epidemic, with 500 million people suffering globally in 2013. Patients cannot successfully manage their diabetic symptoms due to the lack of quality improvement (QI) of diabetic self-management education (DSME). In 2013, this number was 3 to 5 times higher in First Nations populations. The objective of this research is to facilitate better QI and DSME in Indigenous populations across the globe by creating a free, accredited course. This course will educate sustainable health promotion techniques needed for monitoring sugars, mental illness, treating common complications, medication management, and physical and nutritional therapy, to only name a few. Research on the succession will be analyzed in a Public Health practice-based research network (PBRNs) method with surveys, interviews, and statistical analysis on short-/long-term effectiveness from baseline tests. These will include: heart rate, blood pressure, mental health, medication, blood sugar levels >3 months, hyper-/hypo-glycemia, blood circulation, ankle brachial pressure test scores, kidney function, and macrovascular, retinopathy, dermatology and nerve damage complications. These tests will be completed in a small group of remote Indigenous communities in Quebec, Canada. It is hypothesized that this will improve public health efforts of patient self-management of diabetes and its associated symptoms. With this free, accredited, accessible online course to prepare health practitioners in DSME, better glycemic control, less hospital visits, decreased retinopathy, nephropathy, and neuropathy is expected.

Biography:

Mai Xurong is now at the last year of his master program of traditional Chinese medicine at Guangzhou University of Chinese Medicine. His research interests include diabetes, traditional Chinese medicine, and neurology. He has published two papers in the fields of diabetes, traditional Chinese medicine, neurology.

Abstract:

Alzheimer's disease is an age-related degenerative disease of the central nervous system with progressive cognitive impairment and memory impairment. It can be divided into two types: familial hereditary and sporadic. The latter is more, its pathogenesis is unknown, and may be the result of multiple factor interaction. In recent years, people pay more and more attention to the relationship between type 2 diabetes and ad. there have been many reports about learning, memory dysfunction and cognitive impairment in diabetic patients. It is believed that there is a significant correlation between diabetic patients and cognitive impairment. Diabetes can improve the risk of vascular dementia and AD. Some scholars think that AD may be another form of diabetes, and even suggest that ad be called "type 3 diabetes". This article reviews the relationship between them and their possible pathogenesis.

Biography:

Mr. Muhammad Usman, Former Director General of Agricultural Research System, Government of Pakistan who retired from service after a spotless career of about 32 years with senior level experience on research and development of integrated agricultural production, industries, Agriculture & Horticulture and bioenergy on a sustainable way. Mr. Usman is consider as the senior most scientist in the world, always participated in the international conferences as a plenary speaker, keynote speaker, renowned speaker, organizing committee member as well as moderator of the conferences around the world. Mr. Usman established “Prominent Agro Based Industries, Agro Based Industries and Consultancy SDN BHD” in Malaysia and “Foundation for Rural Development in Pakistan”, with primarily aims to work on integrated agricultural project for Rural Development through improvement in agriculture and consultancy services to the formers at Malaysia.

Abstract:

The aim of presentation consist of Harmon, insulin, diabetes disease, global poverty and hunger where studied and reported that Harmon particularly Insulin is the major tool to prevent the diabetes disease for the development of health basic need of daily in the developing countries of the world like South Asia. The study reported that diabetes is a disease that occurs when your blood glucose, also called blood sugar, is too high. The study reported that Insulin, a hormone made by the pancreas, helps glucose from food get into your cells to be used for energy. In other word’s diabetes can strike anyone, from any walk of life. And it does – in numbers that are dramatically increasing. In the last decade, the cases of people living with Diabetes is a chronic, incurable disease that occurs when the body doesn't produce any or enough insulin, leading to an excess of sugar in the blood. Insulin is a hormone, produced by the pancreas, which helps the cells of the body use the glucose (sugar) in food. Cells need this energy in order to function properly. Similarly, diabetes is a disease in which the body’s ability to produce or respond to the hormone insulin is impaired, resulting in abnormal metabolism of carbohydrates and elevated levels of glucose in the blood. The different type of diabetes including Type 1 diabetes used to be called juvenile-onset diabetes. ...Type 2 diabetes used to be called non-insulin dependent diabetes or adult-onset diabetes, and accounts for at least 90% of all cases of diabetes. ... Gestational diabetes (GDM) is a form of diabetes consisting of high blood glucose levels during pregnancy. Similarly the major type diabetes should that there are three major types of diabetes: type 1 diabetes, type 2 diabetes, and gestational diabetes. All types of diabetes mellitus have something in common. Normally, your body breaks down the sugars and carbohydrates you eat into a special sugar called glucose. Glucose fuels the cells in your body. The total number of countries are available in the world are 225, consist of 49 developed countries, 150 developing countries, 4 observers states, 8 state with partial recognition and 14 unrecognized states but the South Asia comprises the countries of Pakistan, Bangladesh, India, Bhutan, Maldives, Nepal and Sri-Lanka South Aisa is about one fifth of the world’s population, which is considered as the most densely populated region in the world. In the light of the above study, it is propose that Harmon particularly insulin should be commercialized to prevent the diabetes disease in the developing countries of the world particularly in South Asia

Biography:

Miao Liu has completed his MPH at the age of 25 years from Peking University and PhD from Chinese PLAgeneral School of Medicine. she is the vice director of biostatistics and associated researcher of institude of geriatrics in Chinese PLA general hospital. She has published more than 40 papers in reputed journals and has been serving as an editorial board member of 3 journals.

Abstract:

There was lack of data about the distribution of ideal cardiovascular health (ICH) status among the oldest and centenarians, and the association with disability and quality of life was unclear. Hence, this study aimed to analyze the distribution characteristics of ICH metrics status of the oldest-old and centenarians, and also to explore the relationships with disability and quality of life. 1002 centenarians from China Hainan Centenarian Cohort Study and 798 oldest-old from the China Hainan Oldest-old Cohort study were included in the analysis. ICH, disability and quality of life were assessed according to standard methods. The median number of ICH metrics among centenarians and oldest-old were 4 (4-5) and 3(3-5) respectively. The highest proportion of ICH metrics at ideal levels were glucose (90.2%), BMI (89.8%), and smoking (89.4%). The disability rates of BADL and IADL decreased with the number of ICH metrics. The EQ-5D vas, EQ-5D score showed increasing trend along with the number of ICH metrics (p<0.05). Compared with centenarians who had only 0-2 ICH metrics, the ORs for BADL disability were0.82(95%CI:0.48-2.72), 0.66(95%CI:0.19-2.24), 0.52(95%CI: 0.15-1.79), 0.44(95%CI:0.29-1.41), and the ORs for IADL disability were  0.74(95%CI:0.41-1.33), 0.65(95%CI:0.35-1.22), 0.58(95%CI:0.32-1.08), 0.41(95%CI:0.19-0.86) for those with 3, 4, 5, ≥6 ICH metrics among centenarians. The results in oldest-old showed similar trends. In conclusion, the ICH metrics of centenarians and oldest-old were at a relatively good level, and there was a strong and independent inverse relationship between with both disability and lower quality of life