21^st Asia Pacific Diabetes Conference

New Diabetes Treatments-Enhanced blood flow

Three diabetes treatments with entirely new modes of action were approved: exenatide injection for people with type 2 diabetes, pramlintide injection as an add-on to insulin therapy for people with type 1 or type 2 diabetes and Sitagliptin also for people with type 2 diabetes. Some diabetes medications help the pancreas release more insulin (if you have type 2 diabetes), others help cells use insulin better, and others keep the liver from releasing too much glucose. The new treatments focus action on hormones called incretins.
Exenatide injection:

• is injected twice a day at mealtime
• is for those with type 2 diabetes who have been unable to control blood glucose with oral medicines
• improves blood glucose control by mimicking incretin hormones, stimulating insulin and slowing stomach-emptying
• leads to weight loss because patients will feel full faster and stop eating
• can cause nausea

Exenatide extended release  is  injected once per week is for those with type 2 diabetes who have been unable to control blood glucose with oral medicines  that helps to improves blood glucose control by mimicking incretin hormones, stimulating insulin and slowing stomach-emptying leads to weight loss because patients will feel full faster and stop eating which can cause nausea.

Pramlintide acetate is intended for those with type 1 or type 2 diabetes who use insulin

• is injected at mealtime
• is to never mix with insulin in one syringe; which creates the need for an additional injection for the patient
• used for better glucose control, reduction in blood glucose spikes, reduction in food intake, whichleads to weight loss
• can cause nausea or hypoglycemia (dangerously low blood glucose)

Sitagliptin Saxagliptin and linagliptin-All three of these pills

• are taken once a day
• are for type 2 diabetes
• do not promote weight gain
• are often used in combination with metformin
• have very little, if any, side effects
• Should be taken with caution for patients with renal disease (dose should be decreased)
• slows the breakdown of incretins, so insulin is released over a longer period of time