Plaban Bhattacharya
University of Calcutta
India
Title: Effect of Triphala in Gestational Diabetes Mellitus
Biography
Biography: Plaban Bhattacharya
Abstract
Severe maternal, foetal and neonatal doldrums are coupled with gestational diabetes mellitus (GDM). Search, validation and implementation of new and safe medications are necessary. Triphala is an ancient herbal formulation effective in several disease conditions. However its effect in GDM is reported to be ambiguous. In the present investigation, the hydro-ethanolic extract of prepared triphala powder was complexed with 2-hydroxypropyl-β-cyclodextrin (BCD), for mainly unpleasant taste masking, bioavailability and stability enhancement. The TR-BCD complex in different dose levels were administered in pregnant, streptozotocin induced diabetic rats. Serum metabolite and antioxidant status, pregnancy outcomes and neonatal malformations were found to be beneficial in comparison to diabetes-control. Liver and kidney histology showed major recovery. Estrus cycle duration and concentration of serum gonadotropin and gonadal hormones were found to be normal in TR-BCD treated group (25 mg/kg/day, administered from day 1 to 16 of pregnancy). The inclusion complex of TR-BCD was characterized by TEM, DLS and HPTLC analyses. TR-BCD nanospheres were found to be a sustained release delivery device and should be explored further to unravel its mechanism of action.