Naveen Reddy Avula
Kasturba Medical College(Kmc)
India
Title: Evaluation of association of hyperuricemia with metabolic syndrome and insulin resistance
Biography
Biography: Naveen Reddy Avula
Abstract
INRODUCTION: The prevalence of hyperuricemia has been increasing in recent years, not only in advanced countries but also in developing countries, along with development of their economy. The metabolic syndrome is a growing public health problem in the world. Components of the metabolic syndrome including Diabetes, Hypertension, Dyslipidaemia.
OBJECTIVE: Our study was performed to evaluate association of hyperuricemia with metabolic syndrome and insulin resistance.
MATERIALS AND METHODS: A total of 60 people with metabolic syndrome were included. Metabolic syndrome was defined as per ATP III guidelines. Hyperuricemia was defined with cutoff >6.8mg/dl in both men and women. Associated work up for metabolic syndrome and insulin resistance like FBS,FLP,FASTING INSULIN,SERUM URIC ACID was done. Blood pressure and anthropometric measurements including weight, height & waist circumferences were measured and BMI calculated. HOMA IR method was used for calculating insulin resistance. Logistic regression analysis was used to evaluate association of hyperuricemia with metabolic syndrome and insulin resistance.
RESULTS: Hyperuricemia was associated with elevated triglyceride levels (p = 0.045 ) and insulin resistance (p = 0.018). There was no significant association of hyperuricemia with other components of metabolic syndrome.
CONCLUSION: Hyperuricemia was associated with elevated triglycerides and insulin resistance.