Shashi Kumar
Manipal University, India
Title: Towards point of care sensing of glycated albumin for better glycemic control
Biography
Biography: Shashi Kumar
Abstract
The prevalence of type 2 diabetes mellitus (T2DM) is rapidly rising worldwide. It has been associated with many micro-vascular and macro-vascular complications1. Among all the complications, peripheral neuropathy is considered to be the most common with prevalence 60 to 65% and 11% patients with diabetic neuropathy complaining of pain2, where 50% of all the inpatient admissions are due to foot complications caused by peripheral neuropathy (DPN)3,4 DPN is a result of injury to the Vasa nervorum, axons and atrophy of the axons leading to tissue damage5. All nerve fibres may be injured, but small myelinated and unmyelinated fibre’s that transmit pain and temperature are most affected6. In association with injury to the nerves, reduced microcirculation of the blood is responsible for the development of ulcers, and infections of skin and bone in T2DM subjects with long duration of diabetes mellitus7. In many subjects with diabetic neuropathy, pain will develop as a symptom localized to the lower extremities, primarily the soles and toes8. Evidences suggest that long term complications of diabetes mellitus are associated with depressive symptoms, the neuropathic pain considered to be one of the major cause for the depression.