Day 3 :
- Track 7: Transplantation of Diabetes
Track 9: Computational Biology of Diabetes
Location: Melia Meeting 8
University of Turin
Title: Prevalence of metabolic syndrome and associated risk factors in medical students of Universidad Central Del Ecuador
Time : 10:00-10:25
Cesar Ruano I. Nieto is Senior Professor in the School of Medical Sciences of the Central University of Ecuador. He obtained the title of MD in the same Faculty and the degree of specialist in Internal Medicine at the Faculty of Medicine of the University of Guayaquil. He studied at the Faculty of Pharmacy of the University of Valencia and the Carlos III Institute. Active member of the Ecuadorian Society of Endocrinology. He has published more than 30 articles in Ecuadorian and foreign Journals. Editor of various scientific journals in Ecuador.
Introduction: There is evidence that obesity increases cardiovascular risk and metabolic syndrome (MS) in children, adolescents and adults. Inflammation plays an important role in the development of these diseases. Today, obesity in children and adolescents is a serious public health problem and appears to be the most important cause of insulin resistance, which makes them a risk group for developing metabolic syndrome.
To determine the prevalence of metabolic syndrome and associated predisposition factors among students of the first three semesters from the school of Medicine, Faculty of Medical Sciences of the “Universidad Central Del Ecuador”.
We included medical students from the first three semesters of the “Universidad Central Del Ecuador”. The students’ weight, height, blood pressure, waist circumference were measure and BMI were calculated. Furthermore, total cholesterol levels in serum, HDL cholesterol, LDL cholesterol, triglycerides, glucose, insulin, hsCRP, IL-6 were determined and the HOMA-IR was calculated. Results:
883 medical students were studied, with a mean age of 19.3±1.4 where 67% were female. The prevalence of MS was 8.2% (n= 73), 68% were women and 32% men. 29.3% of men presented pre obesity or obesity compared with 23.3% of women (p> 0.05). It was found that waist circumference was preferentially altered in women compared to men (52.3% vs 26.2%) (p <0.05). 39.7% of women had HDL levels below the normal values versus 18.2% in males (p <0.05). The values of total cholesterol, LDL cholesterol and glucose were within normal parameters. The blood pressure levels were above the normal range in men more than in women (24.4% vs 9.8%) (p <0.05). 19.4% of the total population presented hsCRP values between 1-3 mg / l and 7.4% between 3-9 mg / l. The 7.48% had altered levels of IL-6 (> 3.1 pg / ml) and was found a slight increase in students with overweight, obesity and MS. Insulin resistance was found in both groups, the one with normal BMI as well as in the overweight and obesity group, 15.3% and 14.4% respectively.
The prevalence of metabolic syndrome was 8.2% and only 34% of the population presented no risk factors for MS. 1 out of 4 students presented some degree of overweight or obesity. A directly proportional relationship between the presence of risk factors and increased blood pressure was evident. Given the large number of individuals who have at least one risk factor, it is crucial to promote a healthy lifestyle that includes non-pharmacological interventions such as diet and exercise.Inflammation
Tehran University of Medical Sciences
Title: The role of preoperative hemoglobin A1c in the occurrence of atrial fibrillation following on-pump coronary artery bypass surgery in type-2 diabetic patients
Time : 10:25-10:50
Akbar Shafiee is currently working in Tehran University of Medical Sciences, Iran.
Several factors can predict the development of atrial fibrillation following cardiac surgery in diabetic patients. Nonetheless, the role of hemoglobin A1c is yet to be investigated. Methods:
We prospectively studied 708 type-2 diabetes patients (433 men [61.2%]), who were candidate for isolated coronary artery bypass grafting and met the study criteria. Biochemistry profile, including serum hemoglobin A1c was measured on the day of operation. All patients were tele-monitored for 72 hours following operation for the occurrence of atrial fibrillation. The patients were then dichotomized at the hemoglobin A1c level of 8% and the frequency of atrial fibrillation, as well as demographic and clinical parameters were compared between the two groups. Results:
The mean age of the study population was 60.83±8.70 years. A total of 109 (15.3%) patients developed atrial fibrillation and in 274 (38.7%) patients hemoglobin A1c was below 8%. There was no significant difference between the two study groups regarding the frequency of atrial fibrillation (P=0.47). There was no statistically significant association between the level of hemoglobin A1c and the occurrence of postoperative atrial fibrillation controlling for age, hypertension, duration of diabetes, serum creatinine, and left atrial size (P=0.50). In the multivariable logistic regression model, age, hypertension, chronic obstructive pulmonary disease, serum creatinine, left atrial size, and full perfusion time were important predictors of atrial fibrillation. Conclusion:
In this study, the association between postoperative atrial fibrillation and the level of hemoglobin A1c was not statistically significant.
Jordan University of Science and Technology
Title: Effect of fresh pomegranate juice on the level of fasting serum glucose, insulin, and melatonin in pre-diabetic individuals
Time : 10:50-11:15
Saleem Ali Banihani has completed his PhD in Clinical Bioanalytical Chemistry from Cleveland Clinic-Cleveland State University joint program. He is currently the Vice Dean of the Faculty of Applied Medical Sciences at Jordan University of Science and Technology, one of the top Universities in the middle east. He has published more than 17 articles in reputed journals in the fields of clinical nutrition and andrology.
Various reports have linked pomegranate (Punica granatum Linn) with diabetes prevention and treatment. However, before pomegranate or any of its fractions can be medically recommended for the management of diabetes, extensive clinical studies are still desired. This study measured the direct effect of fresh pomegranate juice on the level of fasting serum glucose, insulin, and melatonin in subjects with impaired fasting glucose (IFG). Blood samples from 28 participants with impaired fasting glucose were collected after at least 10 hrs fasting, then after 1 and 3 hours from the pomegranate juice administration at 1.5 mL per kg of the body weight. Serum glucose was measured by standard methods using the BS-200 Chemistry Analyzer, while a commercially available immunoassay kits were used to measure human insulin and melatonin. The results from this study observed lower fasting serum glucose levels as well as lower insulin resistance (P<0.05) among the IFG participants after 3 hours of pomegranate juice administration. This hypoglycemic response to pomegranate juice was not affected by the patient's gender and was found to decrease with age. On the other hand, pomegranate juice, after 1 hour of its consumption, was found to decrease the level of serum melatonin, while it increased the level of serum insulin among the tested population. These results offer some encouragement regarding the consumption of pomegranate juice by subjects with IFG.
Hearing & Speech Institute
Soha Mohamed Hamada is working in Audiology department, Hearing and speech Institute in Egypt
Background: Diabetes is a chronic metabolic disease with impaired glucose tolerance. Diabetic neuropathy affects sensory, autonomic, and motor neurons of the peripheral nervous system so that nearly every type of nerve fiber in the body is vulnerable. Objectives: Evaluation of variation in motor functions and postural sway in patients with type 2 diabetes mellitus (DM) and comparing the results with those obtained from control group. This will help in rehabilitation programs for diabetic patients to avoid postural instability and risk of falling. Methodology: forty patients with the diagnosis of type 2 DM (group 1) participated in this study and twenty subjects who had no diagnosis of type 2 DM were evaluated as a control group (group 2). Blood glucose level of patients was measured then they referred to audiovestibular assessment. Computerized dynamic posturography (CDP)was done in form of motor control test and functional limitation assessment; Tandem walk Results: Findings showed statistically significant difference between study group and control group as regards response latency, speed of the forward progression and endpoint sway velocity. A statistically significant correlation was found between response latency and speed of the forward progression with FBS level in study group. Conclusions: Speed of the forward progression was less , however response latency and endpoint sway velocity were more in diabetic patients in comparing with normal subjects. Response latency and speed of the forward progression showed a statistically significant correlation with FBS level in diabetic patients.
University oh Hidalgo Plis
Lourdes Cristina Carrillo Alarcon is perusing her studies in Board of Health Hidalgo and Autonomous University oh Hidalgo Plis, Mexico
OBJECTIVE. To identify the level of knowledge of Type 2 Diabetes Mellitus (T2DM) in patients assigned to the of Diabetes clinics of the Health Services of the state of Hidalgo, Mexico and its relationship with the glycemic level and stage of grief according to Kübler-Ross. MATERIAL & METHODS. A cross-sectional study was performed in 310 patients with T2DM from the Diabetes Clinics of the Health Services of Hidalgo that belong to the Mutual Help Group (GAM, for its initials in Spanish). The patients were given the Diabetes Knowledge Questionnaire (DKQ 24); later a fasting blood glucose sample was taken and an interview (analysis of content) performed in order to identify their stage of grief. For data analysis descriptive statistics, the chi square test, and odds ratio were used. RESULTS. Of the total, 74.2% were women, 37.4% were illiterate and 27.1% had an elementary level education; mean age was 59 ± 11.3 years; 71.6% were housewives; the mean time of evolution of T2DM was 10.4 ± 6.8 years. The mean glycemic level was162.4 ± 74.5 mg/dl. The score of the DKQ 24 was basic knowledge 5.4 ± 1.9, glycemic control 5.4 ± 2.4, complications 7.1 ± .5 and global 5.9 ± 1.5. It was observed that 80.6% did not identify symptoms of hypoglycemia and 50.3% of hyperglycemia; 90.3% of patients did not know vasculopathy prevention measures. Those who were in acceptance managed to control their glycemic levels better than those who were in depression or denial (P <0.05). CONCLUSION. The level of knowledge of diabetic patients regarding their disease was low. These results suggest the importance of evaluating the subject content of the GAM, provide thanatological skills, therapeutics and clinics that allow patients to elaborate their grief and identify warning signs.